A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.

A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors. Research Abstract Details 

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A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors. Abstract Text:

Sumit Deswal,Nilanjan Roy,Sumit Deswal,Nilanjan Roy,

A conventional QSAR study has been carried out using thermodynamic and other descriptors, on a set of arylsulfonamidomethylcyclohexyl derivatives as antagonists of potential obesity drug target human neuropeptide Y Y5 receptor. In addition, a novel range based method was applied to obtain a QSAR model so that the information contained in the compounds for which an approximate value instead of exact value of inhibitory activity was available could be included in the model. Analysis of models suggests that range based model is better in screening biologically active compounds from chemical library. The conventional model is able to predict activity accurately only for active compounds whereas the range based method is better in discriminating active and inactive compounds.

A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors. Publishing Authors By Initials

S Deswal,N Roy,S Deswal,N Roy,

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A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of medicinal chemistry

VOLUME: 42

Page Numbers: 463-70

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ISSN: 0223-5234

DAY: 2

MONTH: 11

YEAR: 2006

A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.

AFFILIATION: Pharmacoinformatics Division, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160062, India.

Country: France

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MEDLINETA: Eur J Med Chem

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