A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.

A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Research Abstract Details 

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A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Abstract Text:

The human forkhead box O1A (FOXO1A) gene belongs to the human forkhead gene family and acts downstream of the human insulin signalling pathway. In this study, polymorphisms of the Intron I of FOXO1A gene were studied in Italian healthy people and insulin resistant subjects. No significant association between the germ-line variability in the Intron I of FOXO1A and insulin resistance was observed. Interestingly, during the study, a new 39-bp sequence insertion polymorphism in Intron I of FOXO1A gene was described. The polymorphism was found to co-segregate in a co-dominant Mendelian fashion and to be present in an ethnically distinct population (Greeks). A BLAST search showed that the sequence shares 100% identity with a mtDNA (mitochondrial DNA) sequence coding for the ATP synthase 8 (ATPase8) and ATP synthase 6 (ATPase6) genes. Hence, FOXO1A Intron I is a polymorphic nuclear region involved in the exchange of DNA material between mitochondrial and genomic DNA, which is a well-established mechanism of evolutionary change in eukaryotes.

A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gene

VOLUME: 327

Page Numbers: 215-9

Journal Abbreviation: Gene

ISSN: 0378-1119

DAY: 3

MONTH: Mar

YEAR: 2004

A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Information

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LANGUAGE: eng

NlmUniqueID: 7706761

A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Information

Substance Name: Adenosine Triphosphatases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.

AFFILIATION: Department of Research and Diabetology Unit, Italian National Research Centers on Ageing, Via Birarelli 8, Ancona 60124, Italy.

Country: Netherlands

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MEDLINETA: Gene

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