A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Abstract Text:

The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences (IRS) has been thought to be essential for mediating these functions. However, using transcriptional profiling, chromatin immunoprecipitation, and functional experiments, we demonstrate that rather than activation of IRS regulated genes (Class I transcripts), transcriptional repression of D-type cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. These data suggest that a novel mechanism of FKHR-mediated gene regulation is linked to its activity as a suppressor of tumor growth.

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Publishing Authors By Initials

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

PUBMED ID PMID:

MEDLINE DATE:

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer cell

VOLUME: 2

Page Numbers: 81-91

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 6

MONTH: Jul

YEAR: 2002

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130617

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: deficiency

Chemical & Substance for Abstract: A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Information

Substance Name: PTEN Phosphohydrolase

Registry Number: EC 3.1.3.67

Grant and Affiliation Information for A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

AFFILIATION: Department of Adult Oncology and Department of Internal Medicine, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA85912

ACRONYM: CA

MEDLINETA: Cancer Cell

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR Related Publications

• 3D imaging and RPE.
• A SIMPLE MODIFICATION OF HOGYES DILUTION METHOD OF PREPARING ANTIRABIC TREATMENT: REPORT ON 3080 TREATMENTS.
• A serological survey of caprine brucellosis in Nigeria.
• African American racial identity across the lifespan: identity status, identity content, and depressive symptoms.
• An Outbreak of Typhoid Fever Due to the Small Colony Variety of Eberthella typhosa.
• Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma.
• Comorbidities and microvascular complications of type 2 diabetes in children and adolescents.
• Do formulation differences alter abuse liability of methylphenidate? A placebo-controlled, randomized, double-blind, crossover study in recreational drug users.
• Four Years' Use of the Kahn Presumptive Test as a Screening Agency in the Serology of Syphilis.
• Frameworks for change.
• Hospital morbidity statistics.
• Identification of prostate cancer modifier pathways using parental strain expression mapping.
• In vitro motility assay to study translocation of actin by myosin.
• Isolated sulfite oxidase deficiency.
• Isolation of Shigella paradysenteriae Type P288 of Boyd from a Case of Acute Diarrhea.
• LABORATORY: A NEW METHOD FOR STAINING NEGRI BODIES OF RABIES.
• Longitudinal trends in mammographic percent density and breast cancer risk.
• Mammographic breast density as a general marker of breast cancer risk.
• No association between 25-hydroxyvitamin D and mammographic density.
• Practical Procedures in the Laboratory Diagnosis of Typhoid and Clinically Related Fevers.
• Procedures Employed by the Laboratories of the Departments of Health in the Various Statesand Some of the Larger Cities of the United States in the Sero-Diagnosis of Syphilis as of December, 1935.
• STATUS OF RABIES IN THE UNITED STATES IN 1921.
• Salmonella Types Isolated in Georgia in 1941-1943, Including a New Type Salmonella georgia.
• Some observations on a record keeping and end-results reporting system.
• Tapeworm Infestations in the Southern United States.
• The Physicians's Statement of Cause of Death.
• The absorption of vitamin A in ruminants and rats.
• The role of mucus in the protection of the gastroduodenal mucosa.
• The status model of racial identity development in African American adolescents: evidence of structure, trajectories, and well-being.
• [Study on the incidence of antibodies to influenza virus type A in medical students.]