A novel loop domain in superantigens extends their T cell receptor recognition site.

A novel loop domain in superantigens extends their T cell receptor recognition site. Research Abstract Details 

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A novel loop domain in superantigens extends their T cell receptor recognition site. Abstract Text:

Sebastian ,Ashok K Varma,Beenu Moza,Katherine J Kasper,Aaron W Wyatt,Penny Zhu,A K M Nur-ur Rahman,Yili Li,Roy A Mariuzza,John K McCormick,Eric J Sundberg,

Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are characterized by the alpha3-beta8 loop, a unique approximately 15 amino acid residue extension that is required for optimal T cell activation. Here, we report the X-ray crystal structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding orientation relative to other SAG-TCR complexes, which results in the alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These interactions are absolutely required for TCR binding and T cell activation by SEK, and dictate the TCR Vbeta domain specificity of SEK and other group V SAGs.

A novel loop domain in superantigens extends their T cell receptor recognition site. Publishing Authors By Initials

S ,AK Varma,B Moza,KJ Kasper,AW Wyatt,P Zhu,AK Rahman,Y Li,RA Mariuzza,JK McCormick,EJ Sundberg,

For similar biological factors: antigens: superantigens research abstracts see: biological factors: antigens: superantigens research

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A novel loop domain in superantigens extends their T cell receptor recognition site. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of molecular biology

VOLUME: 371

Page Numbers: 210-21

Journal Abbreviation: J. Mol. Biol.

ISSN: 0022-2836

DAY: 18

MONTH: 05

YEAR: 2007

A novel loop domain in superantigens extends their T cell receptor recognition site. Information

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LANGUAGE: eng

NlmUniqueID: 2985088

A novel loop domain in superantigens extends their T cell receptor recognition site. Keywords Mesh Terms:

KEYWORDS: Superantigens

MESH TERMS: immunology

Chemical & Substance for Abstract: A novel loop domain in superantigens extends their T cell receptor recognition site. Information

Substance Name: Superantigens

Registry Number: 0

Grant and Affiliation Information for A novel loop domain in superantigens extends their T cell receptor recognition site.

AFFILIATION: Boston Biomedical Research Institute, Watertown, MA 02472, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI036900

ACRONYM: AI

MEDLINETA: J Mol Biol

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