A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation.

A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation. Research Abstract Details 

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A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation. Abstract Text:

Lei Wang,Xing Tang,

Bioadhesive tablet formulations of ketoconazole for vaginal delivery were studied. Carbomer (Carbopol 974P, Carbopol 934P), hydroxypropylmethyl cellulose (HPMC) and hydroxypropyl cellulose (HPC) were used as candidate bioadhesive polymers. Effervescent was incorporated into the formulations as a disintegration agent. The swelling behavior and bioadhesive strength of the drug-free tablets were investigated. Carbopol 934P was selected as biopolymer in combination with HPMC or HPC at different ratios to develop five drug-loaded formulations. The swellings, tackiness and in vitro release were studied on the tablets. A good sustained effect and a moderate bioadhesion were obtained with the tablets. The formulation containing 100mg of effervescent, with the Carbopol 934P:HPC ratio of 1:9, seemed to be the optimum one for the tablet. In vivo drug residence tests were carried out by administering the preferred formulation to female rats. The results showed that the drug remaining followed a one-order model. Even after 24h of administration in vagina of rats, 17% of the original employed drug was retained on the vaginal tissue. Our study may provide a potential vaginal tablet formulation of ketoconazole against Candida albicans.

A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation. Publishing Authors By Initials

L Wang,X Tang,

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A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of pharmaceutics

VOLUME: 350

Page Numbers: 181-7

Journal Abbreviation:

ISSN: 0378-5173

DAY: 31

MONTH: 08

YEAR: 2007

A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation. Information

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LANGUAGE: eng

NlmUniqueID: 7804127

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Grant and Affiliation Information for A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: Design, in vitro and 'in vivo' evaluation.

AFFILIATION: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 110016 Shenyang, PR China.

Country: Netherlands

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MEDLINETA: Int J Pharm

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