A novel class of potent NF-kappaB signaling inhibitors.

A novel class of potent NF-kappaB signaling inhibitors. Research Abstract Details 

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A novel class of potent NF-kappaB signaling inhibitors. Abstract Text:

Johann Leban,Marcel Baierl,Jan Mies,Viola Trentinaglia,Sandra Rath,Kerstin Kronthaler,Kristina Wolf,Astrid Gotschlich,Markus H J Seifert,Johann Leban,Marcel Baierl,Jan Mies,Viola Trentinaglia,Sandra Rath,Kerstin Kronthaler,Kristina Wolf,Astrid Gotschlich,Markus H J Seifert,

A novel class of NF-kappaB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-kappaB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.

A novel class of potent NF-kappaB signaling inhibitors. Publishing Authors By Initials

J Leban,M Baierl,J Mies,V Trentinaglia,S Rath,K Kronthaler,K Wolf,A Gotschlich,MH Seifert,J Leban,M Baierl,J Mies,V Trentinaglia,S Rath,K Kronthaler,K Wolf,A Gotschlich,MH Seifert,

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A novel class of potent NF-kappaB signaling inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5858-62

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 15

MONTH: 08

YEAR: 2007

A novel class of potent NF-kappaB signaling inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for A novel class of potent NF-kappaB signaling inhibitors.

AFFILIATION: 4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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