A novel cholic acid-based contrast enhancement agent for targeted MRI.

A novel cholic acid-based contrast enhancement agent for targeted MRI. Research Abstract Details 

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A novel cholic acid-based contrast enhancement agent for targeted MRI. Abstract Text:

Hyun-Soon Chong,Hyun A Song,Sooyoun Lim,Keith Macrenaris,Xiang Ma,Haisung Lee,Phuong Bui,Thomas Meade,Hyun-Soon Chong,Hyun A Song,Sooyoun Lim,Keith Macrenaris,Xiang Ma,Haisung Lee,Phuong Bui,Thomas Meade,

The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.

A novel cholic acid-based contrast enhancement agent for targeted MRI. Publishing Authors By Initials

HS Chong,HA Song,S Lim,K Macrenaris,X Ma,H Lee,P Bui,T Meade,HS Chong,HA Song,S Lim,K Macrenaris,X Ma,H Lee,P Bui,T Meade,

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A novel cholic acid-based contrast enhancement agent for targeted MRI. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 2505-8

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ISSN: 1464-3405

DAY: 18

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for A novel cholic acid-based contrast enhancement agent for targeted MRI.

AFFILIATION: Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, 3101 S. Dearborn St., LS 182, Chicago, IL 60616, USA.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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