A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis.

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Abstract Text:

Ruiqiong Ran,Ruiqin Pan,Aigang Lu,Huichun Xu,Ryan R Davis,Frank R Sharp,Ruiqiong Ran,Ruiqin Pan,Aigang Lu,Huichun Xu,Ryan R Davis,Frank R Sharp,

A cDNA encoding a novel protein was cloned from ischemic rat brain and found to be homologous to testis Mea-2 Golgi-associated protein (Golga3). The sequence predicted a 165-kDa protein, and in vitro translated protein exhibited a molecular mass of 165-170 kDa. Because brain ischemia induced the mRNA, and the protein localized to the Golgi apparatus, this protein was designated Ischemia-Inducible Golgin Protein 165 (IIGP165). In HeLa cells, serum and glucose deprivation-induced caspase-dependent cleavage of the IIGP165 protein, after which the IIGP165 fragments translocated to the nucleus. The C-terminus of IIGP165, which contains a LXXLL motif, appears to function as a transcriptional co-regulator. Akt co-localizes with IIGP165 protein in the Golgi in vivo, and phosphorylates IIGP165 on serine residues 345 and 134. Though transfection of IIGP165 cDNA alone does not protect HeLa cells from serum deprivation or Brefeldin-A-triggered cell death, co-transfection of both Akt and IIGP165 cDNA or combined IIGP165-transfection with PDGF treatment significantly protects HeLa cells better than either treatment alone. These data show that Akt phosphorylation of IIGP165 protects against apoptotic cell death, and add to evidence that the Golgi apparatus also plays a role in regulating apoptosis.

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Publishing Authors By Initials

R Ran,R Pan,A Lu,H Xu,RR Davis,FR Sharp,R Ran,R Pan,A Lu,H Xu,RR Davis,FR Sharp,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular neurosciences

VOLUME: 36

Page Numbers: 392-407

Journal Abbreviation: Mol. Cell. Neurosci.

ISSN: 1044-7431

DAY: 9

MONTH: 08

YEAR: 2007

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100095

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis.

AFFILIATION: M.I.N.D. Institute and Department of Neurology, University of California at Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA. ruiqiong.ran@ucdmc.ucdavis.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS056302

ACRONYM: NS

MEDLINETA: Mol Cell Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis Related Publications

• A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins.
• A review of sinonasal outcome scoring systems - which is best?
• A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report.
• Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug.
• Adaptation of HIV-1 to its human host.
• An equine fetal monster dicephalus tetrapus dibrachius.
• Bone disease of prematurity.
• Evaluation of mechanisms of postflight orthostatic intolerance with a simple cardiovascular system model.
• Function and localization of microRNAs in mammalian cells.
• Improving care to patients with ischemic heart disease: experiences in a single network of the veterans health administration.
• Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism.
• Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release.
• Internal Knee Forces During Running Off a Platform: 834: June 1 9:45 AM - 10:00 AM.
• Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells.
• Muscle mass deficits are associated with bone mineral density in men with idiopathic vertebral fracture.
• Mycobacterium bovis in rural Tanzania: risk factors for infection in human and cattle populations.
• Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius.
• On rats, refuse, and recycling.
• Pharmacological therapy for people with Alzheimer's disease: the balance of clinical effectiveness, ethical issues and social and healthcare costs.
• Protein-solvent interactions.
• Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain.
• Role of whole foods in promoting hydration after exercise in humans.
• SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage.
• Sh09 antarctic medicine.
• Sh11 the medieval english coroner.
• The routinisation of genomics and genetics: implications for ethical practices.
• Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes.
• Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration.
• Views regarding the training of ethics consultants: a survey of physicians caring for patients in ICU.
• Women's Performance as Wheeled Vehicle Mechanics: 413: 3:40 PM-4:00 PM.