A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation.

A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation. Research Abstract Details 

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A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation. Abstract Text:

A nucleoside carrying a perfluorinated tert-butyl group ( 4) was prepared by a Sonogashira coupling of 5-iodo-2'-deoxyuridine with 4,4,4-trifluoro-3,3-bis(trifluoromethyl)-1-butyne in nearly quantitative yield and subsequently incorporated into DNA oligomers. Thermal denaturation studies showed that 4 had a negligible effect on duplex stabilty when compared to thymidine. Transition from single strand to duplex was monitored by (19)F NMR spectroscopy at micromolar concentrations of oligomers, demonstrating the sensitivity of 4 as an NMR reporter nucleoside.

A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation. Publishing Authors By Initials

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A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 10

Page Numbers: 2745-7

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 6

MONTH: 06

YEAR: 2008

A nonafluoro nucleoside as a sensitive (19)f NMR probe of nucleic Acid conformation. Information

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LANGUAGE: eng

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