A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Research Abstract Details 

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A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Abstract Text:

Anna Benrick,Pernilla Jirholt,Ingrid Wernstedt,Maria Gustafsson,Juergen Scheller,Anna-Lena Eriksson,Jan ,Thomas Hedner,Claes Ohlsson,Torleif ,Stefan Rose-John,John-Olov Jansson,

Inflammation is a key component in the development of atherosclerosis, and myocardial infarction (MI); therefore we investigated the association between an interleukin-6 signal transducer (IL6ST)/gp130 polymorphism, gp130 function and risk of MI. Structural modeling suggested that a non-conservative single nucleotide polymorphism in the gp130, Gly148Arg, can change the stability and functional properties of the molecule. In vitro studies were done with BAF/3 cells lacking endogenous gp130. Cells stably transfected with the gp130 148Arg variant proliferated less and showed slightly lower STAT-3 phosphorylation in response to gp130 stimulation as compared to cells transfected with gp130 148Gly. In a prospectively followed hypertensive cohort we identified 167 patients who suffered a MI during the study and compared them to matched controls (mean age 57 years, 73% males, n=482). Carriers of the 148Arg variant (f(Arg)=0.12) of the gp130 receptor had decreased odds ratio for MI in univariate analysis (0.56, 95% CI 0.34-0.91, p=0.02). In conclusion, a genetically determined structural variant of the IL-6 receptor subunit gp130 is, independently of other known risk factors, associated with decreased risk of MI. The variant is also associated with decreased IL-6 responsiveness and could lead to a configuration change in the gp130 receptor.

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Publishing Authors By Initials

A Benrick,P Jirholt,I Wernstedt,M Gustafsson,J Scheller,AL Eriksson,J ,T Hedner,C Ohlsson,T ,S Rose-John,JO Jansson,

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A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Regulatory peptides

VOLUME: 146

Page Numbers: 189-96

Journal Abbreviation: Regul. Pept.

ISSN: 0167-0115

DAY: 2

MONTH: 10

YEAR: 2007

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Information

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LANGUAGE: eng

NlmUniqueID: 8100479

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Grant and Affiliation Information for A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.

AFFILIATION: Department of Neuroscience and Physiology, Göteborg University, Sweden.

Country: Netherlands

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MEDLINETA: Regul Pept

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