A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes.

A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Research Abstract Details 

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A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Abstract Text:

Robin M Moudy,Mark A Meola,Laura-Lee L Morin,Gregory D Ebel,Laura D Kramer,Robin M Moudy,Mark A Meola,Laura-Lee L Morin,Gregory D Ebel,Laura D Kramer,

Studies examining the evolution of West Nile virus since its introduction into North America have identified the emergence of a new dominant genotype (WN02) that has displaced the introduced genotype (NY99). The mechanistic basis for this displacement, however, remains obscure. Although we found no detectable difference in vitro between the genotypes in either replication or fitness, there were significant differences in vivo in Culex mosquitoes. After peroral infection, the extrinsic incubation period (EIP) of the WN02 genotype was up to 4 days shorter than the EIP of the NY99 genotype; however, after intrathoracic inoculation, there was no difference in EIP between the genotypes, suggesting that differences in genotype interaction with the mosquito midgut are likely to play a role in this phenotype. These results suggest a model for the displacement of the NY99 genotype, where earlier transmission of WN02 viruses leads to higher WN02 infection rates in avian reservoir hosts.

A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Publishing Authors By Initials

RM Moudy,MA Meola,LL Morin,GD Ebel,LD Kramer,RM Moudy,MA Meola,LL Morin,GD Ebel,LD Kramer,

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of tropical medicine and hygi

VOLUME: 77

Page Numbers: 365-70

Journal Abbreviation: Am. J. Trop. Med. Hyg.

ISSN: 0002-9637

DAY: 3

MONTH: Aug

YEAR: 2007

A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Information

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LANGUAGE: eng

NlmUniqueID: 370507

A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: physiology

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Grant and Affiliation Information for A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes.

AFFILIATION: Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Road, Slingerlands, NY 12159, USA. rmoudy@wadsworth.org

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI 055429-03

ACRONYM: AI

MEDLINETA: Am J Trop Med Hyg

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