A new role for P2 receptors: talking with calcium-activated potassium channels.

A new role for P2 receptors: talking with calcium-activated potassium channels. Research Abstract Details 

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A new role for P2 receptors: talking with calcium-activated potassium channels. Abstract Text:

P P Bertrand,P P Bertrand,

Purinergic fast synaptic transmission may play a very subtle role in regulating the excitability of enteric circuits. That is one of the important findings in a new paper by Ren and Galligan in the current issue of this Journal. They first provide compelling evidence that P2X(3) receptors (ionotropic purine receptors) are expressed by guinea-pig motor and interneurons and that these subtypes mediate the purinergic fast excitatory postsynaptic potential (EPSP). They also found that the P2X(3)-mediated depolarization was often followed by a hyperpolarization. This is an intriguing finding because if the purinergic fast EPSPs are also followed by a hyperpolarization, then it could play a role in truncating bursts of synaptic potentials or in shaping periodic synaptic input. The hyperpolarization is caused by calcium entry through the P2X(3) receptor which then activates a calcium-activated potassium (K(Ca)) channel. Surprisingly, the hyperpolarization was not affected by any of the standard blockers of calcium- or voltage-activated K(+) channels suggesting that a novel K(Ca) channel is present in the enteric neurons. Such a wide-spread channel could well have an important physiological role and could be an important new drug target for regulating reflex activity in the enteric nervous system.

A new role for P2 receptors: talking with calcium-activated potassium channels. Publishing Authors By Initials

PP Bertrand,PP Bertrand,

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A new role for P2 receptors: talking with calcium-activated potassium channels. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurogastroenterology and motility : the official

VOLUME: 19

Page Numbers: 865-8

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ISSN: 1350-1925

DAY: 22

MONTH: 10

YEAR: 2007

A new role for P2 receptors: talking with calcium-activated potassium channels. Information

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LANGUAGE: eng

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AFFILIATION: Department of Physiology, School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia. dr.p.bertrand@gmail.com

Country: England

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MEDLINETA: Neurogastroenterol Motil

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