A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B.

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Research Abstract Details 

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A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Abstract Text:

Amos B Smith, ,Akin H Davulcu,

[reaction: see text] Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Publishing Authors By Initials

AB Smith,L ,AH Davulcu,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic letters

VOLUME: 8

Page Numbers: 2167-70

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 11

MONTH: May

YEAR: 2006

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Information

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LANGUAGE: eng

NlmUniqueID: 100890393

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: chemistry

Chemical & Substance for Abstract: A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. Information

Substance Name: nodulisporic acid B

Registry Number: 0

Grant and Affiliation Information for A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B.

AFFILIATION: Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, 19104, USA. smithab@sas.upenn.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM-29028

ACRONYM: GM

MEDLINETA: Org Lett

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