A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor.

A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Research Abstract Details 

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A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Abstract Text:

H Niida,M Okada,K Takeuchi,S Okabe,

Repeated administration of diethyldithiocarbamate (DDC: 750 mg/kg, s.c.), a superoxide dismutase (SOD) inhibitor, to fed rats induced ulcers in the duodenum with less lesion in the stomach. DDC not only reduced basal acid output but also impaired duodenal alkaline secretion under both basal and acid-stimulated conditions. The duodenal ulcers induced by DDC were significantly prevented by either allopurinol, SOD or dmPGE2 at the doses which significantly reversed the inhibited alkaline responses caused by DDC. The pathogenesis of DDC-induced duodenal ulcers may involve impairment of duodenal alkaline secretion, probably caused by insufficiency of antioxidant machinery in the mucosa.

A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Publishing Authors By Initials

H Niida,M Okada,K Takeuchi,S Okabe,

For similar enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research

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A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 162

Page Numbers: 116-9

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1989

A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Information

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LANGUAGE: eng

NlmUniqueID: 437034

A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Keywords Mesh Terms:

KEYWORDS: Superoxide Dismutase

MESH TERMS: pharmacology

Chemical & Substance for Abstract: A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor.

AFFILIATION: Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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