A new method for the catalytic aldol reaction to ketones.

A new method for the catalytic aldol reaction to ketones. Research Abstract Details 

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A new method for the catalytic aldol reaction to ketones. Abstract Text:

Kounosuke Oisaki,Yutaka Suto,Motomu Kanai,Masakatsu Shibasaki,

A new method for the catalytic aldol reaction to ketones, using CuF.3PPh3.2EtOH complex as the catalyst and (EtO)3SiF as the additive, is described. The reaction can be applied to a wide range of ketones and trimethylsilyl enolates. On the basis of mechanistic studies, a working hypothesis for the catalytic cycle is proposed, in which the dynamic ligand exchange mediated by copper silicates produces the active copper enolate. Moreover, the present reaction can be extended to the catalytic enantioselective reaction using tol-BINAP as a chiral ligand.

A new method for the catalytic aldol reaction to ketones. Publishing Authors By Initials

K Oisaki,Y Suto,M Kanai,M Shibasaki,

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A new method for the catalytic aldol reaction to ketones. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 5644-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 14

MONTH: May

YEAR: 2003

A new method for the catalytic aldol reaction to ketones. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A new method for the catalytic aldol reaction to ketones.

AFFILIATION: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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