A new era of cancer therapy: Cancer cell targeted therapies are coming of age.

A new era of cancer therapy: Cancer cell targeted therapies are coming of age. Research Abstract Details 

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A new era of cancer therapy: Cancer cell targeted therapies are coming of age. Abstract Text:

Emilie Voltz,Hinrich Gronemeyer,Emilie Voltz,Hinrich Gronemeyer,

The large majority of today's cancer therapies are based on the removal of solid tumor masses (for example by surgery when possible) and a plethora of chemical or physical treatments such as chemo- and radiotherapy which induce death of particularly sensitive or rapidly growing cells. These approaches are variously combined in order to optimize therapeutic indices. While in some cases, such as childhood leukemia, these treatments may cure patients, it is common knowledge that they are associated with serious side effects. The main conceptual reason for this is that neither cancer cells nor the cancer cause(s) are directly targeted. In addition to a high toxicity and a low quality of life, these traditional therapies can give rise to therapy-induced secondary cancers. Here we will neither discuss the various optimization possibilities nor arguments for and against established therapies. Rather we want to reflect about recent advances, challenges and perspectives of cancer therapeutic concepts which aim at increasing cancer-selectivity. More precisely, we will discuss two such concepts from a cell biological and molecular oncology perspective, namely to (i) target the cause of the cancer and (ii) to (re)activate specific endogenous pathways for cancer cell-selective apoptosis.

A new era of cancer therapy: Cancer cell targeted therapies are coming of age. Publishing Authors By Initials

E Voltz,H Gronemeyer,E Voltz,H Gronemeyer,

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A new era of cancer therapy: Cancer cell targeted therapies are coming of age. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The international journal of biochemistry & cell b

VOLUME: 40

Page Numbers: 1-8

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ISSN: 1357-2725

DAY: 21

MONTH: 09

YEAR: 2007

A new era of cancer therapy: Cancer cell targeted therapies are coming of age. Information

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LANGUAGE: eng

NlmUniqueID: 9508482

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AFFILIATION: Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/CNRS/INSERM/ULP, BP 10142, 67404 Illkirch Cedex, C.U. de Strasbourg, France.

Country: England

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MEDLINETA: Int J Biochem Cell Biol

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