A new drug delivery system utilizing piggyback contact lenses.

A new drug delivery system utilizing piggyback contact lenses. Research Abstract Details 

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A new drug delivery system utilizing piggyback contact lenses. Abstract Text:

We designed and evaluated a new drug delivery system (DDS) in which a drug plate containing levofloxacin was placed between a hydrophilic soft contact lens (SCL) and a non-hydrophilic SCL. The drug plate (diameter 8.0 mm, thickness 0.2 mm) was prepared by coating and freeze-drying a poly(vinyl alcohol) (PVA) disc containing 20, 30 or 40 wt% levofloxacin with a block styrene-(ethylene/butene)-styrene (SEBS) polymer solution. The release rate of the levofloxacin in vitro reduced with an increase in the concentration of SEBS polymer in solution used for coating. The release rate was well controlled and in zero-order kinetics was observed. The drug release from the drug plate consisting of a PVA disc loaded with 30 wt% levofloxacin and coated with 7.5 wt% SEBS polymer solution was 3.07 +/- 0.39 mg during 8 h. This drug plate was placed on an albino rabbit's eye wearing a hydrophilic soft contact lens (SCL), and then covered with a non-hydrophilic SCL. The drug concentrations in the anterior chamber were 156.0 +/- 133.6 micrograms/ml and 193.2 +/- 136.1 micrograms/ml after 4 and 8 h, respectively. The values obtained with frequent instillation of 0.5% levofloxacin every 30 min were 9.9 +/- 4.3 micrograms/ml and 12.5 +/- 10.0 micrograms/ml after 4 and 8 h, respectively. Therefore a significantly higher drug level was achieved with DDS compared to frequent instillation.

A new drug delivery system utilizing piggyback contact lenses. Publishing Authors By Initials

For similar animals: chordata: vertebrates: mammals: lagomorpha: rabbits research abstracts see: animals: chordata: vertebrates: mammals: lagomorpha: rabbits research

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A new drug delivery system utilizing piggyback contact lenses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta ophthalmologica Scandinavica

VOLUME: 74

Page Numbers: 243-8

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Jun

YEAR: 1996

A new drug delivery system utilizing piggyback contact lenses. Information

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LANGUAGE: eng

NlmUniqueID: 9507578

A new drug delivery system utilizing piggyback contact lenses. Keywords Mesh Terms:

KEYWORDS: Rabbits

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: A new drug delivery system utilizing piggyback contact lenses. Information

Substance Name: Ofloxacin

Registry Number: 82419-36-1

Grant and Affiliation Information for A new drug delivery system utilizing piggyback contact lenses.

AFFILIATION: Department of Ophthalmology, School of Medicine, Tokyo Medical and Dental University, Japan.

Country: DENMARK

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MEDLINETA: Acta Ophthalmol Scand

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