A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse.

A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Research Abstract Details 

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A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Abstract Text:

Masako Suzuki,Shun Sato,Yoshikazu Arai,Takashi Shinohara,Satoshi Tanaka,John M Greally,Naka Hattori,Kunio Shiota,Masako Suzuki,Shun Sato,Yoshikazu Arai,Takashi Shinohara,Satoshi Tanaka,John M Greally,Naka Hattori,Kunio Shiota,Masako Suzuki,Shun Sato,Yoshikazu Arai,Takashi Shinohara,Satoshi Tanaka,John M Greally,Naka Hattori,Kunio Shiota,

CpG islands, which have higher GC content and CpG frequencies compared to the genome as a whole, are generally believed to be unmethylated in tissues except at promoters of genes undergoing X chromosome inactivation or genomic imprinting. Recent studies, however, have shown that CpG islands at promoters of a number of genes contain tissue-dependent, differentially methylated regions (T-DMRs). In general, the tissue-specific methylation is restricted to a part of the promoter CpG island, with hypomethylation of the remaining sequence. In the current study, using comparison between Restriction Landmark Genomic Scanning (RLGS) and in silico RLGS, we identified ten sperm-specific unmethylated NotI sites, T-DMRs located in CpG islands that were hypomethylated in sperm but near-completely methylated in the kidney and brain. Unusually, these T-DMRs involve the whole CpG island at each of these loci. We characterized one of these genes, adenine nucleotide translocator 4 (Ant4), which is expressed in germ cells. Using a promoter assay, we demonstrated that expression of Ant4 gene is controlled by DNA methylation at the CpG island sequences within the promoter region. Ant4 and other sperm-specific hypomethylated loci represent a new class of CpG islands that become completely methylated in different cell lineages. T-DMRs at CpG islands are functionally important gene regulatory elements that may now be categorized into two classes: T-DMRs involving a subregion of the CpG island and those that occupy the whole CpG island.

A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Publishing Authors By Initials

M Suzuki,S Sato,Y Arai,T Shinohara,S Tanaka,JM Greally,N Hattori,K Shiota,M Suzuki,S Sato,Y Arai,T Shinohara,S Tanaka,JM Greally,N Hattori,K Shiota,M Suzuki,S Sato,Y Arai,T Shinohara,S Tanaka,JM Greally,N Hattori,K Shiota,

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A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes to cells : devoted to molecular & cellular m

VOLUME: 12

Page Numbers: 1305-14

Journal Abbreviation: Genes Cells

ISSN: 1356-9597

DAY: 13

MONTH: Dec

YEAR: 2007

A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Cellular Biochemistry, Veterinary Medical Sciences/Animal Resource Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

Country: England

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MEDLINETA: Genes Cells

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