A new brief instrument for assessing decisional capacity for clinical research.

A new brief instrument for assessing decisional capacity for clinical research. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A new brief instrument for assessing decisional capacity for clinical research. Abstract Text:

Dilip V Jeste,Barton W Palmer,Paul S Appelbaum,Shahrokh Golshan,Danielle Glorioso,Laura B Dunn,Kathleen Kim,Thomas Meeks,Helena C Kraemer,

CONTEXT: There is a critical need for practical measures for screening and documenting decisional capacity in people participating in different types of clinical research. However, there are few reliable and validated brief tools that could be used routinely to evaluate individuals' capacity to consent to a research protocol. OBJECTIVE: To describe the development, testing, and proposed use of a new practical instrument to assess decision-making capacity: the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC). The UBACC is intended to help investigators identify research participants who warrant more thorough decisional capacity assessment and/or remediation efforts prior to enrollment. DESIGN, SETTING, AND PARTICIPANTS: We developed the UBACC as a 10-item scale that included questions focusing on understanding and appreciation of the information concerning a research protocol. It was developed and tested among middle-aged and older outpatients with schizophrenia and healthy comparison subjects participating in research on informed consent. In an investigation of reliability and validity, we studied 127 outpatients with schizophrenia or schizoaffective disorder and 30 healthy comparison subjects who received information about a simulated clinical drug trial. Internal consistency, interrater reliability, and concurrent (criterion) validity (including correlations with an established instrument as well as sensitivity and specificity relative to 2 potential "gold standard" criteria) were measured. MAIN OUTCOME MEASURES: Reliability and validity of the UBACC. RESULTS: The UBACC was found to have good internal consistency, interrater reliability, concurrent validity, high sensitivity, and acceptable specificity. It typically took less than 5 minutes to administer, was easy to use and reliably score, and could be used to identify subjects with questionable capacity to consent to the specific research project. CONCLUSION: The UBACC is a potentially useful instrument for screening large numbers of subjects to identify those needing more comprehensive decisional capacity assessment and/or remediation efforts.

A new brief instrument for assessing decisional capacity for clinical research. Publishing Authors By Initials

DV Jeste,BW Palmer,PS Appelbaum,S Golshan,D Glorioso,LB Dunn,K Kim,T Meeks,HC Kraemer,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

PUBMED ID PMID:

MEDLINE DATE:

A new brief instrument for assessing decisional capacity for clinical research. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of general psychiatry

VOLUME: 64

Page Numbers: 966-74

Journal Abbreviation: Arch. Gen. Psychiatry

ISSN: 0003-990X

DAY: 3

MONTH: Aug

YEAR: 2007

A new brief instrument for assessing decisional capacity for clinical research. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372435

A new brief instrument for assessing decisional capacity for clinical research. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: diagnosis

Chemical & Substance for Abstract: A new brief instrument for assessing decisional capacity for clinical research. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A new brief instrument for assessing decisional capacity for clinical research.

AFFILIATION: Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, Bldg 13, Fourth Floor, 3350 La Jolla Village Dr, San Diego, CA 92161, USA. djeste@ucsd.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH67002

ACRONYM: MH

MEDLINETA: Arch Gen Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A new brief instrument for assessing decisional capacity for clinical research Related Publications

• A message from the editor-in-chief.
• A new brief instrument for assessing decisional capacity for clinical research.
• Assessment of canine oocyte viability after transportation and storage under different conditions.
• Childhood risk factors for thin body preoccupation and social pressure to be thin.
• Comments on 'Evaluating the added predictive ability of a new marker' by M. Pencina, R. D'Agostino, R. D'Agostino Jr, R. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929).
• Copper(II)-quenched oligonucleotide probes for fluorescent DNA sensing.
• Cost analysis of Jelonet((R)) versus Suprathel((R)) in the management of split-thickness skin graft donor sites.
• DNA-templated metal catalysis.
• Distribution of a triphosphopyridine nucleotide-specific enzyme catalyzing the reversible oxidative decarboxylation of malic acid in higher plants.
• Early pregnancy diagnosis by transrectal ultrasonography in dairy cattle.
• Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial.
• Effects of Muscle ArmorTM Supplementation During a Resistance Training Program on Body Composition and Performance Outcomes In Men: 1587: Board #77 May 30 3:30 PM - 5:00 PM.
• Effects of inhibitors of protein and RNA synthesis on regeneration of surface sialic acid of cells in culture. LA-3610-MS.
• Effects of supportive-expressive group therapy on survival of patients with metastatic breast cancer: a randomized prospective trial.
• Generation of novel adipocyte monolayer cultures from embryonic stem cells.
• Growth inhibition of MCF-7 tumor cell line by phenylacetate linked to functionalized dextran.
• Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein.
• Intracranial intrasellar kissing carotid arteries: case report.
• Long-term effects of mnemonic training in community-dwelling older adults.
• Methods for collecting follicular oocytes from mares.
• Nonsurgical recovery of degenerative ova from the uteri of mares.
• Resistance Training, But Not Aerobic Exercise Training Attenuates The IGFBP-1 Response To Acute Resistance Exercise: 770: May 31 3:45 PM 4:00 PM.
• Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.
• The cost-effectiveness and cost-benefit of screening and brief intervention for unhealthy alcohol use in medical settings.
• The metabolism and effects of contraceptive steroids in primates.
• Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node.
• Ventilation inhomogeneities assessed by the multibreath washout (MBW) technique.
• Xeroderma pigmentosum. A prototype disease of environmental-genetic interaction.
• [Acute asthma attack in children]
• [Etiopathogenetic aspects of allergic pulmonary diseases in childhood]