A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales.

A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Research Abstract Details 

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A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Abstract Text:

Stefano Fusi,Wael F Asaad,Earl K Miller,Xiao-Jing Wang,

Volitional behavior relies on the brain's ability to remap sensory flow to motor programs whenever demanded by a changed behavioral context. To investigate the circuit basis of such flexible behavior, we have developed a biophysically based decision-making network model of spiking neurons for arbitrary sensorimotor mapping. The model quantitatively reproduces behavioral and prefrontal single-cell data from an experiment in which monkeys learn visuomotor associations that are reversed unpredictably from time to time. We show that when synaptic modifications occur on multiple timescales, the model behavior becomes flexible only when needed: slow components of learning usually dominate the decision process. However, if behavioral contexts change frequently enough, fast components of plasticity take over, and the behavior exhibits a quick forget-and-learn pattern. This model prediction is confirmed by monkey data. Therefore, our work reveals a scenario for conditional associative learning that is distinct from instant switching between sets of well-established sensorimotor associations.

A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Publishing Authors By Initials

S Fusi,WF Asaad,EK Miller,XJ Wang,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 54

Page Numbers: 319-33

Journal Abbreviation:

ISSN: 0896-6273

DAY: 19

MONTH: Apr

YEAR: 2007

A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

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Grant and Affiliation Information for A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales.

AFFILIATION: Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS50944

ACRONYM: NS

MEDLINETA: Neuron

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