A network-based method for target selection in metabolic networks.

A network-based method for target selection in metabolic networks. Research Abstract Details 

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A network-based method for target selection in metabolic networks. Abstract Text:

R ,M Sales-Pardo,L A N Amaral,

MOTIVATION: The lack of new antimicrobials, combined with increasing microbial resistance to old ones, poses a serious threat to public health. With hundreds of genomes sequenced, systems biology promises to help in solving this problem by uncovering new drug targets. RESULTS: Here, we propose an approach that is based on the mapping of the interactions between biochemical agents, such as proteins and metabolites, onto complex networks. We report that nodes and links in complex biochemical networks can be grouped into a small number of classes, based on their role in connecting different functional modules. Specifically, for metabolic networks, in which nodes represent metabolites and links represent enzymes, we demonstrate that some enzyme classes are more likely to be essential, some are more likely to be species-specific and some are likely to be both essential and specific. Our network-based enzyme classification scheme is thus a promising tool for the identification of drug targets. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

A network-based method for target selection in metabolic networks. Publishing Authors By Initials

R ,M Sales-Pardo,LA Amaral,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

A network-based method for target selection in metabolic networks. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioinformatics (Oxford, England)

VOLUME: 23

Page Numbers: 1616-22

Journal Abbreviation: Bioinformatics

ISSN: 1460-2059

DAY: 26

MONTH: 04

YEAR: 2007

A network-based method for target selection in metabolic networks. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9808944

A network-based method for target selection in metabolic networks. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: A network-based method for target selection in metabolic networks. Information

Substance Name: Bacterial Proteins

Registry Number: 0

Grant and Affiliation Information for A network-based method for target selection in metabolic networks.

AFFILIATION: Northwestern Institute on Complex Systems and Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA. rguimera@northwestern.edu

Country: England

AGENCY: United States NIGMS

GRANT: K25 GM069546-04

ACRONYM: GM

MEDLINETA: Bioinformatics

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