A necropsy study of Pi phenotypes, emphysema, and smoking.

A necropsy study of Pi phenotypes, emphysema, and smoking. Research Abstract Details 

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A necropsy study of Pi phenotypes, emphysema, and smoking. Abstract Text:

Pi phenotypes, determined post mortem by isoelectric focusing and immunofixation, emphysema, assessed from inflation fixed specimens and smoking history were correlated in 186 hospital necropsies. It was possible to determine Pi phenotype in 98.4% of the specimens. Phenotype M occurred in 87.5%, MZ in a 8.1%, MS in 2.1% and FM in 0.5%. An expected association was found between smoking and emphysema but not between the Pi phenotypes and emphysema. Thus, while smoking is a major aetiological factor, the Pi MZ heterozygous state does not seem to predispose to structural emphysema. However, the small number of cases did not allow an estimation of the risk of smoking in Pi MZ heterozygous persons compared to those with the normal Pi phenotype.

A necropsy study of Pi phenotypes, emphysema, and smoking. Publishing Authors By Initials

For similar skin and connective tissue diseases: connective tissue diseases: alpha 1-antitrypsin deficiency research abstracts see: skin and connective tissue diseases: connective tissue diseases: alpha 1-antitrypsin deficiency research

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A necropsy study of Pi phenotypes, emphysema, and smoking. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 93

Page Numbers: 183-8

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ISSN: 0108-0164

DAY: 26

MONTH: Jul

YEAR: 1985

A necropsy study of Pi phenotypes, emphysema, and smoking. Information

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LANGUAGE: eng

NlmUniqueID: 8206622

A necropsy study of Pi phenotypes, emphysema, and smoking. Keywords Mesh Terms:

KEYWORDS: alpha 1-Antitrypsin Deficiency

MESH TERMS: radiography

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Grant and Affiliation Information for A necropsy study of Pi phenotypes, emphysema, and smoking.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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