A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database.

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Abstract Text:

Tsuo-Feng Wang,Gerald B Kasting,Johannes M Nitsche,Tsuo-Feng Wang,Gerald B Kasting,Johannes M Nitsche,

The full parameterization for the stratum corneum biphasic microtransport model presented previously in this Journal [95:620-648 (2006)] is developed through a combination of fundamental transport theory and calibration with existing data. Of the five microscopic transport properties, four (D(cor), K(cor/w), D(lip), K(lip/w)) are developed from sources independent of the existing steady-state permeability database. The fifth parameter, k(trans) (the mass transfer coefficient for transbilayer hopping), is derived from a fit of the model to the permeability data according to a modified free surface area function of the form log(10) k(trans) = A-B x (MW)(1/3). Examination of the experimental data in terms of the two dimensionless groups, R and sigma, arising from the analysis leads to the conclusion that SC permeation for most compounds is dominated by the transcellular pathway regardless of their lipophilicity, a striking departure from recent skin permeability models. Overall fit of the developed model(s) to the permeability data is somewhat better than for the Potts-Guy equation and variants thereof; however, marked improvement is seen in the estimation of lag times and the related potential for predicting skin hydration effects and transient skin permeation profiles. Simple approximations to the full numerical solution are presented that allow the developed model(s) to be implemented on a spreadsheet.

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Publishing Authors By Initials

TF Wang,GB Kasting,JM Nitsche,TF Wang,GB Kasting,JM Nitsche,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of pharmaceutical sciences

VOLUME: 96

Page Numbers: 3024-51

Journal Abbreviation:

ISSN: 0022-3549

DAY: 5

MONTH: Nov

YEAR: 2007

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985195

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database.

AFFILIATION: Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260-4200, USA.

Country: United States

AGENCY: United States NIOSH

GRANT: R01 OH0075289

ACRONYM: OH

MEDLINETA: J Pharm Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A multiphase microscopic diffusion model for stratum corneum permeability II Estimation of physicochemical parameters, and application to a large permeability database Related Publications

• A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database.
• Assessing the opinions of relatives on the causes and social consequences of different mental disorders: Are instruments cross-culturally valid?
• Boosting focally-induced brain plasticity by dopamine.
• Cortical hypoexcitability in chronic smokers? A transcranial magnetic stimulation study.
• Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing.
• Focusing effect of acetylcholine on neuroplasticity in the human motor cortex.
• Lightest Isotope of Bh Produced via the 209Bi(52Cr,n)260Bh Reaction.
• Limited impact of homeostatic plasticity on motor learning in humans.
• Orthopoxvirus Detection in Environmental Specimens during Suspected Bioterror Attacks: Inhibitory Influences of Common Household Products.
• Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans.
• Rat-to-elephant-to-human transmission of cowpox virus.
• [Case of Kaposi's sarcoma with an unusual location]
• [Concentration of IgA, IgM and IgG in exudates]
• [Echinococcosis]
• [Noise - an important environmental problem]
• [Not Available.]
• [Not Available.]
• [Pilot study of the effect of intravenous prostavasin therapy of inpatients with diabetes mellitus and IIb arterial occlusive disease]
• [Rabies, with special reference to epidemiology and control]
• [Refuse disposal and recycling. What the physician should know about it]
• [The physiology and clinical aspects of magnesium]
• [The soul also participates in the bath]