A mouse model of orthotopic vascularized aerated lung transplantation.

A mouse model of orthotopic vascularized aerated lung transplantation. Research Abstract Details 

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A mouse model of orthotopic vascularized aerated lung transplantation. Abstract Text:

M Okazaki,A S Krupnick,C G Kornfeld,J M Lai,J H Ritter,S B Richardson,H J Huang,N A Das,G A Patterson,A E Gelman,D Kreisel,

Outcomes after lung transplantation are markedly inferior to those after other solid organ transplants. A better understanding of cellular and molecular mechanisms contributing to lung graft injury will be critical to improve outcomes. Advances in this field have been hampered by the lack of a mouse model of lung transplantation. Here, we report a mouse model of vascularized aerated single lung transplantation utilizing cuff techniques. We show that syngeneic grafts have normal histological appearance with minimal infiltration of T lymphocytes. Allogeneic grafts show acute cellular rejection with infiltration of T lymphocytes and recipient-type antigen presenting cells. Our data show that we have developed a physiological model of lung transplantation in the mouse, which provides ample opportunity for the study of nonimmune and immune mechanisms that contribute to lung allograft injury.

A mouse model of orthotopic vascularized aerated lung transplantation. Publishing Authors By Initials

M Okazaki,AS Krupnick,CG Kornfeld,JM Lai,JH Ritter,SB Richardson,HJ Huang,NA Das,GA Patterson,AE Gelman,D Kreisel,

For similar surgical procedures, operative: transplantation: transplantation, homologous: transplantation, isogeneic research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous: transplantation, isogeneic research

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A mouse model of orthotopic vascularized aerated lung transplantation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 1672-9

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 3

MONTH: Jun

YEAR: 2007

A mouse model of orthotopic vascularized aerated lung transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 100968638

A mouse model of orthotopic vascularized aerated lung transplantation. Keywords Mesh Terms:

KEYWORDS: Transplantation, Isogeneic

MESH TERMS: physiology

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Grant and Affiliation Information for A mouse model of orthotopic vascularized aerated lung transplantation.

AFFILIATION: Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Country: Denmark

AGENCY: United States NHLBI

GRANT: 1R43HL87456-01

ACRONYM: HL

MEDLINETA: Am J Transplant

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