A module of negative feedback regulators defines growth factor signaling.

A module of negative feedback regulators defines growth factor signaling. Research Abstract Details 

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A module of negative feedback regulators defines growth factor signaling. Abstract Text:

Ido Amit,Ami Citri,Tal Shay,Yiling Lu,Menachem Katz,Fan Zhang,Gabi Tarcic,Doris Siwak,John Lahad,Jasmine Jacob-Hirsch,Ninette Amariglio,Nora Vaisman,Eran Segal,Gideon Rechavi,Uri Alon,Gordon B Mills,Eytan Domany,Yosef Yarden,

Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regulation of transcription and mRNA stability, we demonstrate that a number of genes within the delayed early gene cluster function as feedback regulators of immediate early genes. Consistent with their role in negative regulation of cell signaling, genes within this cluster are downregulated in diverse tumor types, in correlation with clinical outcome. More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks.

A module of negative feedback regulators defines growth factor signaling. Publishing Authors By Initials

I Amit,A Citri,T Shay,Y Lu,M Katz,F Zhang,G Tarcic,D Siwak,J Lahad,J Jacob-Hirsch,N Amariglio,N Vaisman,E Segal,G Rechavi,U Alon,GB Mills,E Domany,Y Yarden,

For similar proteins: dna-binding proteins: tristetraprolin research abstracts see: proteins: dna-binding proteins: tristetraprolin research

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A module of negative feedback regulators defines growth factor signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature genetics

VOLUME: 39

Page Numbers: 503-12

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 25

MONTH: 02

YEAR: 2007

A module of negative feedback regulators defines growth factor signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216904

A module of negative feedback regulators defines growth factor signaling. Keywords Mesh Terms:

KEYWORDS: Tristetraprolin

MESH TERMS: physiology

Chemical & Substance for Abstract: A module of negative feedback regulators defines growth factor signaling. Information

Substance Name: Extracellular Signal-Regulated MAP Kinas

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for A module of negative feedback regulators defines growth factor signaling.

AFFILIATION: Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.

Country: United States

AGENCY: United States NCI

GRANT: CA72981

ACRONYM: CA

MEDLINETA: Nat Genet

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