A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts.

A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Research Abstract Details 

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A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Abstract Text:

Larry A Adamson,Wei-Chao Huang,Warren C Breidenbach,Dina Rahhal,Hong Xu,Yiming Huang,Diane J Pidwell,Fu-Chan Wei,Gordon Tobin,Suzanne T Ildstad,

Composite tissue allotransplantation (CTA) is the new frontier in transplantation. More than 25 hand allograft transplants have been performed worldwide, and the feasibility has been well established. The classical experimental model of CTA involves rat orthotopic hindlimb transplantation, a time-consuming procedure associated with high mortality and morbidity. We describe a rat heterotopic osteomyocutaneous flap that serves as a nonfunctional CTA, allowing the study of tolerance induction to a highly antigenic vascularized allograft of bone, muscle, and skin while minimizing the morbidity and mortality of full hind limb transplantation. In the present studies, we explored whether establishing chimerism by nonmyeloablative conditioning would induce tolerance to CTA. When compared with the classic hind limb transplantation model, these results demonstrate that our heterotopic hind limb flap is less morbid and as an effective experimental model for the study of CTA tolerance.

A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Publishing Authors By Initials

LA Adamson,WC Huang,WC Breidenbach,D Rahhal,H Xu,Y Huang,DJ Pidwell,FC Wei,G Tobin,ST Ildstad,

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A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Microsurgery

VOLUME: 27

Page Numbers: 630-6

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ISSN: 0738-1085

DAY: 16

MONTH: 10

YEAR: 2007

A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Information

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LANGUAGE: eng

NlmUniqueID: 8309230

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Grant and Affiliation Information for A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts.

AFFILIATION: Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202-1760, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 1 R01 HL063442

ACRONYM: HL

MEDLINETA: Microsurgery

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