A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo.

A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Research Abstract Details 

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A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Abstract Text:

Hui Meng,Daniel D Swartz,Zhijie Wang,Yiemeng Hoi,John Kolega,Eleni M Metaxa,Michael P Szymanski,Junichi Yamamoto,Eric Sauvageau,Elad I Levy,

OBJECTIVE: Cerebral aneurysms are preferentially located at arterial bifurcation apices with complex hemodynamics. To understand disease mechanisms associated with aneurysm initiation, we attempted to establish a causal relationship between local hemodynamics and vascular responses. METHODS: Arterial bifurcations were surgically created from native common carotid arteries in two dogs, angiographically imaged 2 weeks and 2 months later, and then excised. We characterized local morphological changes in response to specifically manipulated hemodynamics. Computational fluid dynamics simulations were performed on the in vivo images and results mapped onto histological images. RESULTS: Local flow conditions, such as high wall shear stress and high wall shear stress gradient, were found to be associated with vascular changes, including an intimal pad in the flow impingement region and a "groove" bearing the characteristics of an early aneurysm. CONCLUSION: This novel method of histohemodynamic micromapping reveals a direct correlation between an altered hemodynamic microenvironment and vascular responses consistent with aneurysm development.

A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Publishing Authors By Initials

H Meng,DD Swartz,Z Wang,Y Hoi,J Kolega,EM Metaxa,MP Szymanski,J Yamamoto,E Sauvageau,EI Levy,

For similar biomechanics: stress, mechanical research abstracts see: biomechanics: stress, mechanical research

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A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neurosurgery

VOLUME: 59

Page Numbers: 1094-100; discussion 1100-1

Journal Abbreviation: Neurosurgery

ISSN: 1524-4040

DAY: 3

MONTH: Nov

YEAR: 2006

A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 7802914

A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Keywords Mesh Terms:

KEYWORDS: Stress, Mechanical

MESH TERMS: methods

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Grant and Affiliation Information for A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo.

AFFILIATION: Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA. huimeng@buffalo.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS047242

ACRONYM: NS

MEDLINETA: Neurosurgery

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