A mixed state core for melancholia: an exploration in history, art and clinical science.

A mixed state core for melancholia: an exploration in history, art and clinical science. Research Abstract Details 

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A mixed state core for melancholia: an exploration in history, art and clinical science. Abstract Text:

H S Akiskal,K K Akiskal,

OBJECTIVE: We argue for a mixed state core for melancholia comparing concepts of melancholia across centuries using examples from art, history and scientific literature. METHOD: Literature reviews focusing on studies from Kraepelin onward, DSM-IV classification and view-points from clinical experience highlighting phenomenologic and biologic features as predictors of bipolar outcome in prospective studies of depression. RESULTS: Despite the implied chemical pathology in the term endogenous/melancholic depression, frequently reported glucocortical and sleep neurophysiologic abnormalities, there is little evidence that melancholia is inherited independently from more broadly defined depressions. Prospective follow-up of 'neurotic' depressions have shown melancholic outcomes in as many as a third; hypomania has also been observed in such follow-up. CONCLUSION: These findings and considerations overall do suggest that melancholia as defined today is more closely aligned with the depressive and/or mixed phase of bipolar disorder. Given the high suicidality from many of these patients the practice of treating them with antidepressant monotherapy needs re-evaluation.

A mixed state core for melancholia: an exploration in history, art and clinical science. Publishing Authors By Initials

HS Akiskal,KK Akiskal,

For similar behavioral disciplines and activities: behavioral sciences: psychiatry research abstracts see: behavioral disciplines and activities: behavioral sciences: psychiatry research

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A mixed state core for melancholia: an exploration in history, art and clinical science. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME:

Page Numbers: 44-9

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ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 2007

A mixed state core for melancholia: an exploration in history, art and clinical science. Information

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LANGUAGE: eng

NlmUniqueID: 370365

A mixed state core for melancholia: an exploration in history, art and clinical science. Keywords Mesh Terms:

KEYWORDS: Psychiatry

MESH TERMS: history

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Grant and Affiliation Information for A mixed state core for melancholia: an exploration in history, art and clinical science.

AFFILIATION: University of California at San Diego, La Jolla, CA, USA. hakiskal@ucsd.edu

Country: Denmark

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MEDLINETA: Acta Psychiatr Scand Suppl

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