A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants.

A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants. Research Abstract Details 

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A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants. Abstract Text:

Wolfgang Frank,Kim-Miriam Baar,Enas Qudeimat,Mayada Woriedh,Ali Alawady,Diah Ratnadewi,Louis Gremillon,Bernhard Grimm,Ralf Reski,Wolfgang Frank,Kim-Miriam Baar,Enas Qudeimat,Mayada Woriedh,Ali Alawady,Diah Ratnadewi,Louis Gremillon,Bernhard Grimm,Ralf Reski,

The cloning of abiotic stress-inducible genes from the moss Physcomitrella patens led to the identification of the gene PpTSPO1, encoding a protein homologous to the mammalian mitochondrial peripheral-type benzodiazepine receptor and the bacterial tryptophane-rich sensory protein. This class of proteins is involved in the transport of intermediates of the tetrapyrrole biosynthesis pathway. Like the mammalian homologue, the PpTSPO1 protein is localized to mitochondria. The generation of PpTSPO1-targeted moss knock-out lines revealed an essential function of the gene in abiotic stress adaptation. Under stress conditions, the PpTSPO1 null mutants show elevated H(2)O(2) levels, enhanced lipid peroxidation and cell death, indicating an important role of PpTSPO1 in redox homeostasis. We hypothesize that PpTSPO1 acts to direct porphyrin precursors to the mitochondria for heme formation, and is involved in the removal of photoreactive tetrapyrrole intermediates.

A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants. Publishing Authors By Initials

W Frank,KM Baar,E Qudeimat,M Woriedh,A Alawady,D Ratnadewi,L Gremillon,B Grimm,R Reski,W Frank,KM Baar,E Qudeimat,M Woriedh,A Alawady,D Ratnadewi,L Gremillon,B Grimm,R Reski,

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A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Plant journal : for cell and molecular biology

VOLUME: 51

Page Numbers: 1004-18

Journal Abbreviation: Plant J.

ISSN: 0960-7412

DAY: 25

MONTH: 07

YEAR: 2007

A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants. Information

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LANGUAGE: eng

NlmUniqueID: 9207397

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Grant and Affiliation Information for A mitochondrial protein homologous to the mammalian peripheral-type benzodiazepine receptor is essential for stress adaptation in plants.

AFFILIATION: Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr. 1, 79104 Freiburg, Germany. wolfgang.frank@biologie.uni-freiburg.de

Country: England

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MEDLINETA: Plant J

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ACCESSION NUMBER: DQ645823

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