A microfabrication method of a biodegradable polymer chip for a controlled release system.

A microfabrication method of a biodegradable polymer chip for a controlled release system. Research Abstract Details 

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A microfabrication method of a biodegradable polymer chip for a controlled release system. Abstract Text:

Yoshihiro Ito,Hirokazu Hasuda,Masatoshi Morimatsu,Nobuyuki Takagi,Yoshihiko Hirai,

A simple microfabrication method for a controlled-release drug-delivery system has been designed using biodegradable polymeric microchips. Microholes were made in a poly(L-lactic acid) plate and dyes were cast in each well. After drying, the wells were sealed with polymers having different biodegradation rates using a mold that had hollows corresponding to the wells. The polymers were prepared by mixing polylactides with the co-polymers. The sealing was confirmed by ultrasonication. The plate was incubated in phosphate-buffered saline and the dye released from the plate as the degradation proceeded was detected spectrophotometrically. The higher the degradation rate of the polymer sealing, the faster the sealed dye was released. This biodegradable biochip is useful for the design of controlled-release drug-delivery systems.

A microfabrication method of a biodegradable polymer chip for a controlled release system. Publishing Authors By Initials

Y Ito,H Hasuda,M Morimatsu,N Takagi,Y Hirai,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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A microfabrication method of a biodegradable polymer chip for a controlled release system. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 16

Page Numbers: 949-55

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2005

A microfabrication method of a biodegradable polymer chip for a controlled release system. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

A microfabrication method of a biodegradable polymer chip for a controlled release system. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: chemistry

Chemical & Substance for Abstract: A microfabrication method of a biodegradable polymer chip for a controlled release system. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for A microfabrication method of a biodegradable polymer chip for a controlled release system.

AFFILIATION: Kanagawa Academy of Science and Technology, KSP East 309, 3-2-1 Sakado, Takatsu-ku, Kawasaki, 213-0012, Japan. y-ito@ksp.or.jp

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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