A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells.

A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Research Abstract Details 

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A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Abstract Text:

Yizhen Chen,Eric Antoniou,Zhilin Liu,Leonard B Hearne,R Michael Roberts,

Interferon-tau (IFNT) is released by preimplantation conceptuses of ruminant species and prepares the mother for pregnancy. Although one important function is to protect the corpus luteum from the luteolytic activity of prostaglandin-F 2alpha, IFNT most likely regulates a range of other physiological processes in endometrium. Here, an immortalized cell line from ovine uterine luminal epithelial cells was treated with IFNT for either 8 or 24 h. RNA was subjected to cDNA microarray analysis, with RNA from untreated cells as the reference standard. Of 15 634 genes, 1274 (8%) were IFNT responsive at P<0.01 and 585 at P<0.001 to at least one treatment. Of the latter, 356 were up-regulated and 229 down-regulated. Increasing IFNT concentrations from 10 ng/ml to 10 microg/ml had minor effects, and most genes up- or down-regulated at 8 h were regulated similarly at 24 h. Although IFNT influences many genes implicated in antiviral activity and apoptosis, its action also likely regulates prostaglandin metabolism, growth factors and their receptors, apoptosis and the nuclear factor (NF)-kappaB cascade, extracellular matrix accretion, angiogenesis, blood coagulation, and inflammation. In particular, it increased mRNA concentrations of genes related to the vascular endothelial growth factor R2 pathway of angiogenesis and down-regulated ones associated with hypoxia. Two genes implicated in the antiluteolytic actions of IFNT (encoding cyclooxygenase-2 and the oxytocin receptor respectively) were down-regulated in response to all treatments. IFNT targets a complex range of physiological processes during the establishment of pregnancy.

A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Publishing Authors By Initials

Y Chen,E Antoniou,Z Liu,LB Hearne,RM Roberts,

For similar urogenital system: genitalia: genitalia, female: uterus research abstracts see: urogenital system: genitalia: genitalia, female: uterus research

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A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Reproduction (Cambridge, England)

VOLUME: 134

Page Numbers: 123-35

Journal Abbreviation: Reproduction

ISSN: 1470-1626

DAY: 3

MONTH: Jul

YEAR: 2007

A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100966036

A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Keywords Mesh Terms:

KEYWORDS: Uterus

MESH TERMS: metabolism

Chemical & Substance for Abstract: A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells. Information

Substance Name: trophoblastin

Registry Number: 0

Grant and Affiliation Information for A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells.

AFFILIATION: Division of Animal Sciences, University of Missouri-Columbia, Missouri 65211, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD 21896

ACRONYM: HD

MEDLINETA: Reproduction

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