A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine.

A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Research Abstract Details 

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A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Abstract Text:

A procedure is described for the radioiodination of proteins using an iodinated derivative of N-succinimidyl 3-(tri-n-butylstannyl) benzoate (ATE). Adequate removal of unreacted ATE from [125I]ATE was necessary for optimal protein radioiodination. Labeling efficiencies of greater than 60% could be obtained after a 20 min incubation of goat IgG with [125I]ATE at 4 degrees C. Paired-label experiments with goat IgG labeled with 125I using ATE and 131I using Iodogen demonstrated that use of the ATE reagent for protein labeling significantly reduced (P less than 0.005) the thyroid uptake of radioiodine.

A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Publishing Authors By Initials

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of radiation applications an

VOLUME: 38

Page Numbers: 1051-5

Journal Abbreviation:

ISSN: 0883-2889

DAY: 26

MONTH: 02

YEAR: 1987

A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Information

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LANGUAGE: eng

NlmUniqueID: 8611097

A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Information

Substance Name: Urea

Registry Number: 57-13-6

Grant and Affiliation Information for A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine.

AFFILIATION: Department of Radiology, Duke University Medical Center, Durham, NC 27710.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA 42324

ACRONYM: CA

MEDLINETA: Int J Rad Appl Instrum [A]

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