A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber.

A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Research Abstract Details 

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A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Abstract Text:

Joseph F Antognini,Richard J Atherley,Michael J Laster,Earl Carstens,Robert C Dutton,Edmond I Eger,

The limited potency of nitrous oxide mandates the use of a hyperbaric chamber to produce anesthesia. Use of a hyperbaric chamber complicates anesthetic delivery, ventilation, and electrophysiological recording. We constructed a hyperbaric acrylic-aluminum chamber allowing recording of single unit activity in spinal cord of rats anesthetized only with N(2)O. Large aluminum plates secured to each other by rods that span the length of the chamber close each end of the chamber. The 122 cm long, 33 cm wide chamber housed ventilator, intravenous infusion pumps, recording headstage, including hydraulic microdrive and stepper motors (controlled by external computers). Electrical pass-throughs in the plates permitted electrical current or signals to enter or leave the chamber. In rats anesthetized only with N(2)O we recorded extracellular action potentials with a high signal-to-noise ratio. We also recorded electroencephalographic activity. This technique is well-suited to study actions of weak anesthetics such as N(2)O and Xe at working pressures of 4-5 atm or greater. The safety of such pressures depends on the wall thickness and chamber diameter.

A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Publishing Authors By Initials

JF Antognini,RJ Atherley,MJ Laster,E Carstens,RC Dutton,EI Eger,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neuroscience methods

VOLUME: 160

Page Numbers: 215-22

Journal Abbreviation: J. Neurosci. Methods

ISSN: 0165-0270

DAY: 11

MONTH: 10

YEAR: 2006

A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Information

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LANGUAGE: eng

NlmUniqueID: 7905558

A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: physiology

Chemical & Substance for Abstract: A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. Information

Substance Name: Nitrous Oxide

Registry Number: 10024-97-2

Grant and Affiliation Information for A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber.

AFFILIATION: Department of Anesthesiology and Pain Medicine, University of California, Davis, TB-170, Davis, CA 95616, USA. jfantognini@ucdavis.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM61283

ACRONYM: GM

MEDLINETA: J Neurosci Methods

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