A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Research Abstract Details 

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A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Abstract Text:

Heather M Ochs-Balcom,Georgia Wiesner,Robert C Elston,

The N-acetyltransferase 2 gene (NAT2) product is an enzyme important in carcinogen metabolism via activation and detoxification pathways. Therefore, NAT2 variants may represent underlying susceptibility to breast cancer. Because a number of studies of the association of NAT2 with breast cancer have been published, the authors performed a meta-analysis. They extracted all relevant data to examine evidence for a main effect (i.e., the effect in a model that does not include any interactions) of NAT2 phenotype and genotype on breast cancer risk. They summarized the evidence for modification by smoking and meat intake, sources of exposure to aromatic and heterocyclic amines, respectively, which are metabolized by NAT2. The authors identified seven studies that measured NAT2 phenotype and 20 studies that deduced phenotype via genotyping. They found no evidence for heterogeneity (Cochran's Q statistic p=0.74) and no statistically significant increased risk from NAT2 acetylation (slow/rapid) for breast cancer (summary odds ratio=1.02, 95% confidence interval: 0.95, 1.08). These results suggest that there is no overall association between the NAT2 slow- or rapid-acetylation phenotype and breast cancer risk. However, some evidence suggests that smoking may modify this association.

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Publishing Authors By Initials

HM Ochs-Balcom,G Wiesner,RC Elston,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of epidemiology

VOLUME: 166

Page Numbers: 246-54

Journal Abbreviation: Am. J. Epidemiol.

ISSN: 0002-9262

DAY: 29

MONTH: 05

YEAR: 2007

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Information

Number of References: 55

LANGUAGE: eng

NlmUniqueID: 7910653

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: adverse effects

Chemical & Substance for Abstract: A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Information

Substance Name: NAT2 protein, human

Registry Number: EC 2.3.1.5

Grant and Affiliation Information for A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.

AFFILIATION: Department of Epidemiology and Biostatistics, Case Western Reserve University, and Ireland Comprehensive Cancer Center at University Hospitals of Cleveland, OH 44106-7281, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR03655

ACRONYM: RR

MEDLINETA: Am J Epidemiol

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