A mechanical spike accompanies the action potential in Mammalian nerve terminals.

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Abstract Text:

Large and rapid changes in light scattering accompany secretion from nerve terminals of the mammalian neurohypophysis (posterior pituitary). In the mouse, these intrinsic optical signals are intimately related to the arrival of the action potential E-wave and the release of arginine vasopressin and oxytocin (S-wave). Here we have used a high bandwidth atomic force microscope to demonstrate that these light-scattering signals are associated with changes in terminal volume that are detected as nanometer-scale movements of a cantilever positioned on top of the neurohypophysis. The most rapid mechanical response ("spike"), having a duration shorter than the action potential but comparable to that of the E-wave, represents a transient increase in terminal volume due to water movement associated with Na(+)-influx. The slower mechanical event ("dip"), on the other hand, depends upon Ca(2+)-entry as well as on intraterminal Ca(2+)-transients and, analogously to the S-wave, seems to monitor events associated with secretion.

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Publishing Authors By Initials

For similar nervous system: synapses research abstracts see: nervous system: synapses research

PUBMED ID PMID:

MEDLINE DATE:

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 3122-9

Journal Abbreviation:

ISSN: 0006-3495

DAY: 16

MONTH: 02

YEAR: 2007

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370626

A mechanical spike accompanies the action potential in Mammalian nerve terminals. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: A mechanical spike accompanies the action potential in Mammalian nerve terminals. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A mechanical spike accompanies the action potential in Mammalian nerve terminals.

AFFILIATION: Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6074, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS40966

ACRONYM: NS

MEDLINETA: Biophys J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A mechanical spike accompanies the action potential in Mammalian nerve terminals Related Publications

• A computational survey of candidate exonic splicing enhancer motifs in the model plant Arabidopsis thaliana.
• A mechanical spike accompanies the action potential in Mammalian nerve terminals.
• A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes.
• Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg.
• Bioinformatics challenges of new sequencing technology.
• Hawkeye: an interactive visual analytics tool for genome assemblies.
• Human K10 epithelial keratin is the most abundant protein in airborne dust of both occupied and unoccupied school rooms.
• Identifying bacterial genes and endosymbiont DNA with Glimmer.
• Is RAS Blockade Routinely Indicated in Hypertensive Kidney Transplant Patients?
• It is time to end the patenting of software.
• JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions.
• Posterior tuberculous sinuses of vertebral origin; wound revision and closure with streptomycin permitting early spinal fusion.
• Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptake.
• Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18.
• Subcutaneous mastectomy and immediate reconstruction for prevention of breast cancer for high-risk patients.
• The contents of the syringe.
• The neurologist, psychogenic nonepileptic seizures, and borderline personality disorder.
• The use of streptomycin in thoracoplasty for pulmonary tuberculosis.
• Transtracheal anesthesia for bronchoscopy.
• Two-photon excitation of potentiometric probes enables optical recording of action potentials from Mammalian nerve terminals in situ.
• Using GlimmerM to Find Genes in Eukaryotic Genomes.
• [Humana banana cereal in daily practice]
• [Treatment of acute diarrhea in pediatrics with Streptococcus faecium: results of a double blind study]