A major difference between transdetermination and homeosis.

A major difference between transdetermination and homeosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A major difference between transdetermination and homeosis. Abstract Text:

J Karlsson,

IN Drosophila, the adult structures arise from nests of larval cells called imaginal disks, whose state of determination with respect to disk type is usually fixed. However, two processes are known which can change determination from one disk type to another; one occurs in situ and is due to homeotic mutations, and the other is seen after culture of disk material and is called transdetermination. Similarities between the two, notably the lack of intermediate states, have led to the idea that they are different aspects of the same phenomenon(1,2). The existence of homeotic mutations argues that determination in normal development is underlain by a genetic switching mechanism(3,4); transdetermination could result from epigenetic changes in this system. If this is so then the two phenomena should have characteristics in common. Studies of homeotic mutants have shown that a structure in one disk is always transformed into a specific structure from the other disk(5,6); for example clones of bithorax in an anterior dorsal position in the haltere show anterior dorsal wing structures(5). This is used as a criterion of homology, and also indicates that all disks use the same positional information(7). Differences between disks must be due to different interpretation of this information, mediated in some way by the wild-type alleles of the homeotic genes. It is not yet known whether transdetermination also shows position-specific transformation; if the two phenomena are closely related then this should be the case. It is often assumed to be so, because there have been reports of transdetermination between leg and antenna in which structures such as claw and arista, thought from homeotic mutants to be homologous, are found adjacent to one another in implants(1). However, these findings could also be explained by non-homologous transdetermination followed by either movement together of homologous structures due to preferential cell affinities, or intercalary regeneration between the non-homologous structures. Also, regeneration before transdetermination can give misleading results. One cannot simply ask to what structures a given disk fragment will transdetermine as the fragment might regenerate the rest of the disk first, and non-regenerating (that is duplicating) fragments do not appear to transdetermine (unpublished observations, and ref. 8). One solution to these problems is to find a disk in which transdetermination occurs only in one part, and this is the case in the foreleg disk. The experiments reported here were designed to find whether this part transdetermines to a homologous part of the wing disk.

A major difference between transdetermination and homeosis. Publishing Authors By Initials

J Karlsson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A major difference between transdetermination and homeosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature

VOLUME: 279

Page Numbers: 426-8

Journal Abbreviation: Nature

ISSN: 0028-0836

DAY: 31

MONTH: May

YEAR: 1979

A major difference between transdetermination and homeosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 410462

A major difference between transdetermination and homeosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A major difference between transdetermination and homeosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A major difference between transdetermination and homeosis.

AFFILIATION:

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nature

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A major difference between transdetermination and homeosis Related Publications

• A flexible measurement system for physiological signals in mobile health care.
• A major difference between transdetermination and homeosis.
• A monocyte-specific peptide from herpes simplex virus type 2 glycoprotein G activates the NADPH-oxidase but not chemotaxis through a G-protein-coupled receptor distinct from the members of the formyl peptide receptor family.
• A new approach for studying correlations between the chemical structure and the rheological properties in carboxymethyl cellulose.
• Adaptive spatio-temporal filtration of bioelectrical signals.
• An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.
• An integrated model for the effect of budesonide on ACTH and cortisol in healthy volunteers.
• Analytical strategies for the quality assessment of recycled high-impact polystyrene: a combination of thermal analysis, vibrational spectroscopy, and chromatography.
• Characterization of gangliosides of epithelial cells of calf small intestine, with special reference to receptor-active sequences for enteropathogenic Escherichia coli K99.
• Clinical use and material wear of polymeric tracheostomy tubes.
• Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method.
• Drying rate variations of latex dispersions due to salt induced skin formation.
• Efficient nanosecond optical parametric oscillators based on periodically poled KTP emitting in the 1.8-2.5-mum spectral region.
• First-order type II quasi-phase-matched UV generation in periodically poled KTP.
• Glycosylation of sputum mucins is altered in cystic fibrosis patients.
• Hydraulic and mechanical properties of young Norway spruce clones related to growth and wood structure.
• Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies.
• Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
• Murine models of acute neuronopathic Gaucher disease.
• Nonoperatively treated burst fractures of the thoracic and lumbar spine in adults: a 23- to 41-year follow-up.
• Personality disorders and change in personality.
• Polarization mode dispersion induced pulse broadening in optical fibers.
• Reduced-order modeling, error estimation, and the role of the start-vector: the recursive residue generation method revisited.
• Short-term effects of metformin in type 2 diabetes.
• Small-scale analysis of O-linked oligosaccharides from glycoproteins and mucins separated by gel electrophoresis.
• Spectral characterization of human EHG frequency components based on the extraction and reconstruction of the ridges in the scalogram.
• Statistical aspects of van't Hoff analysis: a simulation study.
• Temporal relationship between infestation with lice (Bovicola ovis Schrank) and the development of pruritic behaviour and fleece derangement in sheep.
• Variations in the axis of motion during head repositioning--a comparison of subjects with whiplash-associated disorders or non-specific neck pain and healthy controls.
• Vulnerability to psychosis increases the risk of depression. Results of the RADEP study.