A machine learning approach for the identification of odorant binding proteins from sequence-derived properties.

A machine learning approach for the identification of odorant binding proteins from sequence-derived properties. Research Abstract Details 

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A machine learning approach for the identification of odorant binding proteins from sequence-derived properties. Abstract Text:

Ganesan Pugalenthi,Ke Tang,P N Suganthan,G Archunan,R Sowdhamini,Ganesan Pugalenthi,Ke Tang,P N Suganthan,G Archunan,R Sowdhamini,

BACKGROUND: Odorant binding proteins (OBPs) are believed to shuttle odorants from the environment to the underlying odorant receptors, for which they could potentially serve as odorant presenters. Although several sequence based search methods have been exploited for protein family prediction, less effort has been devoted to the prediction of OBPs from sequence data and this area is more challenging due to poor sequence identity between these proteins. RESULTS: In this paper, we propose a new algorithm that uses Regularized Least Squares Classifier (RLSC) in conjunction with multiple physicochemical properties of amino acids to predict odorant-binding proteins. The algorithm was applied to the dataset derived from Pfam and GenDiS database and we obtained overall prediction accuracy of 97.7% (94.5% and 98.4% for positive and negative classes respectively). CONCLUSION: Our study suggests that RLSC is potentially useful for predicting the odorant binding proteins from sequence-derived properties irrespective of sequence similarity. Our method predicts 92.8% of 56 odorant binding proteins non-homologous to any protein in the swissprot database and 97.1% of the 414 independent dataset proteins, suggesting the usefulness of RLSC method for facilitating the prediction of odorant binding proteins from sequence information.

A machine learning approach for the identification of odorant binding proteins from sequence-derived properties. Publishing Authors By Initials

G Pugalenthi,K Tang,PN Suganthan,G Archunan,R Sowdhamini,G Pugalenthi,K Tang,PN Suganthan,G Archunan,R Sowdhamini,

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A machine learning approach for the identification of odorant binding proteins from sequence-derived properties. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BMC bioinformatics

VOLUME: 8

Page Numbers: 351

Journal Abbreviation: BMC Bioinformatics

ISSN: 1471-2105

DAY: 19

MONTH: 09

YEAR: 2007

A machine learning approach for the identification of odorant binding proteins from sequence-derived properties. Information

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LANGUAGE: eng

NlmUniqueID: 100965194

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Grant and Affiliation Information for A machine learning approach for the identification of odorant binding proteins from sequence-derived properties.

AFFILIATION: School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore. ganesan@ntu.edu.sg

Country: England

AGENCY: United Kingdom Wellcome T

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MEDLINETA: BMC Bioinformatics

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