A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study.

A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Research Abstract Details 

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A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Abstract Text:

Isao Saito,Shinichi Sato,Masakazu Nakamura,Yoshihiro Kokubo,Toshifumi Mannami,Hisashi Adachi,Masamitsu Konishi,Katsutoshi Okada,Hiroyasu Iso,Kazuomi Kario,Fumitaka Ohsuzu,Yukihiko Momiyama,Motoo Tsushima,Isao Saito,Shinichi Sato,Masakazu Nakamura,Yoshihiro Kokubo,Toshifumi Mannami,Hisashi Adachi,Masamitsu Konishi,Katsutoshi Okada,Hiroyasu Iso,Kazuomi Kario,Fumitaka Ohsuzu,Yukihiko Momiyama,Motoo Tsushima,Isao Saito,Shinichi Sato,Masakazu Nakamura,Yoshihiro Kokubo,Toshifumi Mannami,Hisashi Adachi,Masamitsu Konishi,Katsutoshi Okada,Hiroyasu Iso,Kazuomi Kario,Fumitaka Ohsuzu,Yukihiko Momiyama,Motoo Tsushima,

High-sensitivity C-reactive protein (hs-CRP) levels vary remarkably by race and ethnic group. We examined hs-CRP levels and their association with cardiovascular risk factors in the Japanese general population. The Japan National Cardiovascular Center (NCVC)-collaborative Inflammation Cohort (JNIC) Study recruited 5213 men and 7071 women aged > or = 40 years from seven communities in Japan during 2002-2004. hs-CRP was measured using nephelometry calibrated with CRM 470, the international plasma protein reference material. Traditional cardiovascular risk factors and their aggregation were studied in multivariate logistic models, stratified by overweight status. Median hs-CRP levels in men and women were 0.60 and 0.45 mg/L, respectively. The percentage of subjects with hs-CRP levels < 1.0, 1.0-3.0, and > 3.0 mg/L was 67.4%, 22.0%, and 10.6% in men, respectively, and 76.3%, 16.7%, and 7.0% in women. hs-CRP levels showed significant linear associations with traditional risk factors. Overweight, hypertension, dyslipidemia (men only), smoking (men only), and diabetes (women only) contributed significantly to elevated hs-CRP levels. Overweight individuals with hypertension, dyslipidemia, and diabetes had a high prevalence of elevated hs-CRP levels in both sexes. Japanese adults have very low hs-CRP levels. An aggregation of metabolic risk factors is associated with elevated hs-CRP levels among overweight individuals, particularly in women.

A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Publishing Authors By Initials

I Saito,S Sato,M Nakamura,Y Kokubo,T Mannami,H Adachi,M Konishi,K Okada,H Iso,K Kario,F Ohsuzu,Y Momiyama,M Tsushima,I Saito,S Sato,M Nakamura,Y Kokubo,T Mannami,H Adachi,M Konishi,K Okada,H Iso,K Kario,F Ohsuzu,Y Momiyama,M Tsushima,I Saito,S Sato,M Nakamura,Y Kokubo,T Mannami,H Adachi,M Konishi,K Okada,H Iso,K Kario,F Ohsuzu,Y Momiyama,M Tsushima,

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A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 194

Page Numbers: 238-44

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 11

MONTH: 09

YEAR: 2006

A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study. Information

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LANGUAGE: eng

NlmUniqueID: 242543

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Grant and Affiliation Information for A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: the Japan NCVC-Collaborative Inflammation Cohort (JNIC) study.

AFFILIATION: Department of Public Health Policy, Nara Medical University, Kashihara, Japan. saitoi@m.ehime-u.ac.jp

Country: Ireland

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MEDLINETA: Atherosclerosis

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