A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis.

A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Research Abstract Details 

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A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Abstract Text:

Fifty-two patients with retinal vasculitis--26 with idiopathic disease and 26 with associated systemic inflammatory disease--were followed up for periods ranging from six months to 12 years. The aim of the study was to determine the relationship between relapse of uveitis, visual outcome, and the occurrence of circulating immune complexes (CIC) and antiretinal antibodies. In a total of 69 relapses, CIC were increased in one-third of patients and antiretinal antibodies in one-half. In those 34 patients who expressed antiretinal antibodies 27 (79%) of the relapses were characterised by antiretinal antibodies in the absence of raised CIC levels (p less than 0.01). These findings support our previous hypothesis that CIC may have a protective role in autoimmune retinal vasculitis and that antiretinal autoimmunity is of pathogenetic importance in relapse. In individual patients the visual outcome was not related to the number of relapses or to the CIC-autoantibody pattern, suggesting the operation of additional features which merit identification.

A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Publishing Authors By Initials

For similar cardiovascular diseases: vascular diseases: vasculitis research abstracts see: cardiovascular diseases: vascular diseases: vasculitis research

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A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 72

Page Numbers: 442-7

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Jun

YEAR: 1988

A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Information

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LANGUAGE: eng

NlmUniqueID: 421041

A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Keywords Mesh Terms:

KEYWORDS: Vasculitis

MESH TERMS: immunology

Chemical & Substance for Abstract: A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Information

Substance Name: Autoantibodies

Registry Number: 0

Grant and Affiliation Information for A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis.

AFFILIATION: Department of Immunology, United Medical School, St Thomas's Campus, London.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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