A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.

A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Research Abstract Details 

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A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Abstract Text:

Amanda H McDaniel,Xia Li,Michael G Tordoff,Alexander A Bachmanov,Danielle R Reed,

To identify the gene or genes on mouse Chromosome 9 that contribute to strain differences in fatness, we conducted an expanded mapping analysis to better define the region where suggestive linkage was found, using the F(2 )generation of an intercross between the C57BL/6ByJ and 129P3/J mouse strains. Six traits were studied: the summed weight of two adipose depots, the weight of each depot, analyzed individually (the gonadal and retroperitoneal depot), and the weight of each depot (summed and individual) relative to body size. We found significant linkage (LOD = 4.6) that accounted for the relative weight of the summed adipose depots, and another for the relative weight of the gonadal (LOD = 5.3) but not retroperitoneal (LOD = 0.9) adipose depot. This linkage is near marker rs30280752 (61.1 Mb, Build 34) and probably is equivalent to the quantitative trait locus (QTL) Adip5. Because the causal gene is unknown, we identified and evaluated several candidates within the confidence interval with functional significance to the body fatness phenotype (Il18, Acat1, Cyp19a1, Crabp1, Man2c1, Neil1, Mpi1, Csk, Lsm16, Adpgk, Bbs4, Hexa, Thsd4, Dpp8, Anxa2, and Lipc). We conclude that the Adip5 locus is specific to the gonadal adipose depot and that a gene or genes near the linkage peak may account for this QTL.

A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Publishing Authors By Initials

AH McDaniel,X Li,MG Tordoff,AA Bachmanov,DR Reed,

For similar genetic structures: genome: genome components: genes: quantitative trait loci research abstracts see: genetic structures: genome: genome components: genes: quantitative trait loci research

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A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Mammalian genome : official journal of the Interna

VOLUME: 17

Page Numbers: 1078-92

Journal Abbreviation: Mamm. Genome

ISSN: 0938-8990

DAY: 10

MONTH: 11

YEAR: 2006

A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Information

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LANGUAGE: eng

NlmUniqueID: 9100916

A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Keywords Mesh Terms:

KEYWORDS: Quantitative Trait Loci

MESH TERMS: genetics

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Grant and Affiliation Information for A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.

AFFILIATION: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01DK058797

ACRONYM: DK

MEDLINETA: Mamm Genome

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