A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone.

A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Research Abstract Details 

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A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Abstract Text:

Andrew J Burghardt,Galateia J Kazakia,Sharmila Majumdar,

High resolution peripheral quantitative computed tomography (HR-pQCT) is a promising method for detailed in vivo 3D characterization of the densitometric, geometric, and microstructural features of human bone. Currently, a hybrid densitometric, direct, and plate model-based calculation is used to quantify trabecular microstructure. In the present study, this legacy methodology is compared to direct methods derived from a new local thresholding scheme independent of densitometric and model assumptions. Human femoral trabecular bone samples were acquired from patients undergoing hip replacement surgery. HR-pQCT (82 microm isotropic voxels) and micro-tomography (16 microm isotropic voxels) images were acquired. HR-pQCT images were segmented and analyzed in three ways: (1) using the hybrid method provided by the manufacturer based on a fixed global threshold, (2) using direct 3D methods based on the fixed global threshold segmentation, and (3) using direct 3D methods based on a novel local threshold scheme. The results were compared against standard direct 3D indices from microCT analysis. Standard trabecular parameters determined by HR-pQCT correlated strongly to microCT. BV/TV and Tb.Th were significantly underestimated by the hybrid method and significantly overestimated by direct methods based on the global threshold segmentation while the local method yielded optimal intermediate results. The direct-local method also performed favorably for Tb.N (R(2) = 0.85 vs. R(2) = 0.70 for direct-global method) and Tb.Sp (R(2) = 0.93 vs. R(2) = 0.85 for the hybrid method and R(2) = 0.87 for the direct-global method). These results indicate that direct methods, with the aid of advanced segmentation techniques, may yield equivalent or improved accuracy for quantification of trabecular bone microstructure without relying on densitometric or model assumptions.

A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Publishing Authors By Initials

AJ Burghardt,GJ Kazakia,S Majumdar,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of biomedical engineering

VOLUME: 35

Page Numbers: 1678-86

Journal Abbreviation:

ISSN: 0090-6964

DAY: 30

MONTH: 06

YEAR: 2007

A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Information

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LANGUAGE: eng

NlmUniqueID: 361512

A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: methods

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Grant and Affiliation Information for A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone.

AFFILIATION: Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94158, USA. andrew.burghardt@radiology.ucsf.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG17762

ACRONYM: AG

MEDLINETA: Ann Biomed Eng

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