A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.

A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Research Abstract Details 

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A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Abstract Text:

Jonathan Savitz,Lize van der Merwe,Mark Solms,Rajkumar Ramesar,

The identification of the genetic variants underpinning bipolar disorder (BPD) has been impeded by a complex pattern of inheritance characterized by genetic and phenotypic heterogeneity, genetic epistasis, and gene-environment interactions. In this paper two strategies were used to ameliorate these confounding factors. A unique South African sample including 190 individuals of the relatively, reproductively isolated Afrikaner population was assessed with a battery of neuropsychological tests in an attempt to identify a BPD-associated quantitative trait or endophenotype. BPD individuals performed significantly worse than their unaffected relatives on visual and verbal memory tasks, a finding congruent with the literature. Afocused linkage and family-based association study was carried out using this memory-related endophenotype. In the largest 77-strong Afrikaner pedigree significant evidence for linkage was detected on chromosome 22q11, a region previously implicated in BPD. The quantitative transmission disequilibrium tests-based association analysis suggested that functional variants of the DRD4 and MAO-A genes modulate memory-related cognition. We speculate that polymorphisms at these loci may predispose to a subtype of BPD characterized by memory-related deficits.

A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Publishing Authors By Initials

J Savitz,L van der Merwe,M Solms,R Ramesar,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuromolecular medicine

VOLUME: 9

Page Numbers: 101-16

Journal Abbreviation: Neuromolecular Med.

ISSN: 1535-1084

DAY: 3

MONTH: 12

YEAR: 2007

A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Information

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LANGUAGE: eng

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A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.

AFFILIATION: Division of Human Genetics, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. savitz@mail.nih.gov

Country: United States

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MEDLINETA: Neuromolecular Med

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