A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues.

A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Research Abstract Details 

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A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Abstract Text:

M Z Ratajczak,B Machalinski,W Wojakowski,J Ratajczak,M Kucia,

Accumulating evidence demonstrates that adult tissues contain a population of stem cells that express early developmental markers such as stage-specific embryonic antigen and transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells and primordial germ cells. The presence of these stem cells in adult tissues including bone marrow, epidermis, bronchial epithelium, myocardium, pancreas and testes supports the concept that adult tissues contain some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. In this review we will discuss these data and present a hypothesis that these cells could be direct descendants of the germ lineage. The germ lineage in order to pass genes on to the next generations creates soma and thus becomes a 'mother lineage' for all somatic cell lineages present in the adult body.

A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Publishing Authors By Initials

MZ Ratajczak,B Machalinski,W Wojakowski,J Ratajczak,M Kucia,

For similar cells: stem cells: pluripotent stem cells research abstracts see: cells: stem cells: pluripotent stem cells research

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A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Journal Published:

PUBLICATION TYPE: Review

Journal: Leukemia : official journal of the Leukemia Societ

VOLUME: 21

Page Numbers: 860-7

Journal Abbreviation:

ISSN: 0887-6924

DAY: 8

MONTH: 03

YEAR: 2007

A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Information

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LANGUAGE: eng

NlmUniqueID: 8704895

A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Keywords Mesh Terms:

KEYWORDS: Pluripotent Stem Cells

MESH TERMS: cytology

Chemical & Substance for Abstract: A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Information

Substance Name: Octamer Transcription Factor-3

Registry Number: 0

Grant and Affiliation Information for A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues.

AFFILIATION: Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA. mzrata01@louisville.edu

Country: England

AGENCY: United States NCI

GRANT: R01 CA106281-01

ACRONYM: CA

MEDLINETA: Leukemia

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