A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Abstract Text:

Anne-Laure Sellier-Leclerc,Arnaud Duval, Riveron,Marie-Alice Macher,Georges Deschenes,Chantal Loirat,Marie-Christine Verpont,Michel Peuchmaur,Pierre Ronco,Renato C Monteiro,Elie Haddad,

Idiopathic nephrotic syndrome is characterized by glomerular proteinuria in the absence of infiltrating cells or immunoglobulin deposits. Although it is suspected that T cells secrete a circulating factor that leads to proteinuria by altering the permeability of the glomerular filtration barrier, the precise etiology of this syndrome is unknown. Because an animal model that mimics human idiopathic nephrotic syndrome does not exist, we developed a humanized mouse model of the disease by injecting CD34(+) stem cells or CD34(-) peripheral blood mononuclear cells from afflicted patients into immunocompromised mice. Even though both CD34(+) and CD34(-) cells induced the engraftment of human CD45(+) leukocytes in mice, only the injection of CD34(+) stem cells induced albuminuria. Ultrastructural analysis of glomeruli from the resulting proteinuric mice revealed effacement of podocyte foot processes, similar to the pathology observed in the human disease. Therefore, our data suggest that the cells responsible for the pathogenesis of idiopathic nephrotic syndrome are more likely to be immature differentiating cells rather than mature peripheral T cells.

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Publishing Authors By Initials

AL Sellier-Leclerc,A Duval,S Riveron,MA Macher,G Deschenes,C Loirat,MC Verpont,M Peuchmaur,P Ronco,RC Monteiro,E Haddad,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Society of Nephrology : JA

VOLUME: 18

Page Numbers: 2732-9

Journal Abbreviation: J. Am. Soc. Nephrol.

ISSN: 1046-6673

DAY: 12

MONTH: 09

YEAR: 2007

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9013836

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.

AFFILIATION: INSERM U699, Faculté de Médecine Denis Diderot, Université Paris 7, France.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Soc Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells Related Publications

• 2006 Lebanese radiology workforce report.
• A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.
• Activity of the beta-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism.
• Adverse effects of antipsychotics as outcome measures.
• Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.
• CT scan findings of occult sinus pathology in asymptomatic individuals.
• Cell death in an ischemic infarct rim model.
• Chronic high-inspired CO2 decreases excitability of mouse hippocampal neurons.
• Delayed traumatic intracerebral hematoma: Case report and review of literature.
• Development of discriminatory multiple-locus variable number tandem repeat analysis for Bartonella henselae.
• Discordant tissue-specific expression of SAPK/MAPK(JNK)-related cofactors in hypoxia and hypoxia/reoxygenation in a model of anoxia-tolerance.
• Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia.
• Effect of carbon dioxide on neonatal mouse lung: a genomic approach.
• Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
• Factors influencing cell fate in the infarct rim.
• Fluorinated ethylenepropylene copolymer as a potential capillary material in CE.
• Hypoxia increases BK channel activity in the inner mitochondrial membrane.
• Identification of inorganic improvised explosive devices by analysis of postblast residues using portable capillary electrophoresis instrumentation and indirect photometric detection with a light-emitting diode.
• Insulin-sensitizing and Anti-proliferative Effects of Argania spinosa Seed Extracts.
• Male infertility.
• Prevalence and characteristics of metabolic syndrome in 111 Royal Jordanian Air Force pilots.
• Prostaglandin transporter expression in mouse brain during development and in response to hypoxia.
• Regulation of the Antisense Beta Myosin Heavy Chain Promoter: 939: June 2 9:45 AM - 10:00 AM.
• Reliable electrophoretic mobilities free from Joule heating effects using CE.
• Synthesis and secretion of transferrin by a bovine trabecular meshwork cell line.
• The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK(ERK): discordant proteomic effect of MAPK(p38).
• The time of perception and the other way around.
• [Description of an outbreak of lepidopterism (dermatitis associated with contact with moths) among sailors in Salvador, State of Bahia]
• [Illusions: a window into perception]
• [The "de Sèze" magnetic imaging]