A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs.

A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Research Abstract Details 

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A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Abstract Text:

Tatsuo Kawamoto,Nobuyoshi Motohashi,Atsushi Kitamura,Yoshiyuki Baba,Koichiro Takahashi,Shoichi Suzuki,Takayuki Kuroda,

OBJECTIVE: The purpose of this preliminary study was to examine experimental tooth movement into newly generated bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2). METHOD: After extraction of the maxillary first premolars, bone defects were surgically created in eight adult beagle dogs using a 5-mm-diameter trepan bar. According to which material was grafted into the bone defects, animals were divided into the following four groups: (1) the rhBMP-2 group in which rhBMP-2 with a poly[ D,L-(lactide-co-glycolide)]/gelatin sponge complex was implanted; (2) the spongiosa group in which spongiosa from the tibia was grafted; (3) the nongrafted group in which no material was embedded; and (4) the control group in which only tooth extraction was performed. The osteoinductive activity of rhBMP-2 and tooth movement into the newly generated bone were examined by histological and morphometric comparisons of each group. RESULTS: Considerable new bone formation was observed at the grafted site both in the rhBMP-2 and in the spongiosa groups. The area of generated bone in the rhBMP-2 group was significantly greater than that in the spongiosa group. Newly generated bone, in both the rhBMP-2 and spongisosa groups, showed a similar histological response to orthodontic force as in normal alveolar bone in the control group. However, root resorption occurred on the pressure side in the rhBMP-2 group. CONCLUSION: These results indicated that rhBMP-2 might constitute an alternative material to autogeneous bone grafting for alveolar cleft defects. Further studies regarding tooth movement into generated bone induced by rhBMP-2 are suggested.

A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Publishing Authors By Initials

T Kawamoto,N Motohashi,A Kitamura,Y Baba,K Takahashi,S Suzuki,T Kuroda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Cleft palate-craniofacial journal : official p

VOLUME: 39

Page Numbers: 439-48

Journal Abbreviation: Cleft Palate Craniofac. J.

ISSN: 1055-6656

DAY: 19

MONTH: Jul

YEAR: 2002

A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Information

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LANGUAGE: eng

NlmUniqueID: 9102566

A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: adverse effects

Chemical & Substance for Abstract: A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs.

AFFILIATION: , Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. t-kawamoto.mort@tmd.ac.jp

Country: United States

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MEDLINETA: Cleft Palate Craniofac J

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