A high-resolution map of segmental DNA copy number variation in the mouse genome.

A high-resolution map of segmental DNA copy number variation in the mouse genome. Research Abstract Details 

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A high-resolution map of segmental DNA copy number variation in the mouse genome. Abstract Text:

Timothy A Graubert,Patrick Cahan,Deepa Edwin,Rebecca R Selzer,Todd A Richmond,Peggy S Eis,William D Shannon,Xia Li,Howard L McLeod,James M Cheverud,Timothy J Ley,

Submicroscopic (less than 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. In some cases, CNVs that cause gene dosage effects have been implicated in phenotypic variation. CNVs have been detected in diverse species, including mice and humans. Published studies in mice have been limited by resolution and strain selection. We chose to study 21 well-characterized inbred mouse strains that are the focus of an international effort to measure, catalog, and disseminate phenotype data. We performed comparative genomic hybridization using long oligomer arrays to characterize CNVs in these strains. This technique increased the resolution of CNV detection by more than an order of magnitude over previous methodologies. The CNVs range in size from 21 to 2,002 kb. Clustering strains by CNV profile recapitulates aspects of the known ancestry of these strains. Most of the CNVs (77.5%) contain annotated genes, and many (47.5%) colocalize with previously mapped segmental duplications in the mouse genome. We demonstrate that this technique can identify copy number differences associated with known polymorphic traits. The phenotype of previously uncharacterized strains can be predicted based on their copy number at these loci. Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits.

A high-resolution map of segmental DNA copy number variation in the mouse genome. Publishing Authors By Initials

TA Graubert,P Cahan,D Edwin,RR Selzer,TA Richmond,PS Eis,WD Shannon,X Li,HL McLeod,JM Cheverud,TJ Ley,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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A high-resolution map of segmental DNA copy number variation in the mouse genome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: PLoS genetics

VOLUME: 3

Page Numbers: e3

Journal Abbreviation: PLoS Genet.

ISSN: 1553-7404

DAY: 22

MONTH: 11

YEAR: 2006

A high-resolution map of segmental DNA copy number variation in the mouse genome. Information

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LANGUAGE: eng

NlmUniqueID: 101239074

A high-resolution map of segmental DNA copy number variation in the mouse genome. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: A high-resolution map of segmental DNA copy number variation in the mouse genome. Information

Substance Name: DNA Probes

Registry Number: 0

Grant and Affiliation Information for A high-resolution map of segmental DNA copy number variation in the mouse genome.

AFFILIATION: Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, Missouri, United States of America. graubert@medicine.wustl.edu

Country: United States

AGENCY: United States NHGRI

GRANT: T32 HG000045

ACRONYM: HG

MEDLINETA: PLoS Genet

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