A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus.

A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Research Abstract Details 

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A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Abstract Text:

Roman Biek,J Caroline Henderson,Lance A Waller,Charles E Rupprecht,Leslie A Real,

Emerging pathogens potentially undergo rapid evolution while expanding in population size and geographic range during the course of invasion, yet it is generally difficult to demonstrate how these processes interact. Our analysis of a 30-yr data set covering a large-scale rabies virus outbreak among North American raccoons reveals the long lasting effect of the initial infection wave in determining how viral populations are genetically structured in space. We further find that coalescent-based estimates derived from the genetic data yielded an amazingly accurate reconstruction of the known spatial and demographic dynamics of the virus over time. Our study demonstrates the combined evolutionary and population dynamic processes characterizing the spread of pathogen after its introduction into a fully susceptible host population. Furthermore, the results provide important insights regarding the spatial scale of rabies persistence and validate the use of coalescent approaches for uncovering even relatively complex population histories. Such approaches will be of increasing relevance for understanding the epidemiology of emerging zoonotic diseases in a landscape context.

A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Publishing Authors By Initials

R Biek,JC Henderson,LA Waller,CE Rupprecht,LA Real,

For similar bacterial infections and mycoses: zoonoses research abstracts see: bacterial infections and mycoses: zoonoses research

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A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 7993-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 30

MONTH: 04

YEAR: 2007

A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Keywords Mesh Terms:

KEYWORDS: Zoonoses

MESH TERMS: epidemiology

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Grant and Affiliation Information for A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus.

AFFILIATION: Department of Biology and Center for Disease Ecology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA. rbiek@emory.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01-AI047498

ACRONYM: AI

MEDLINETA: Proc Natl Acad Sci U S A

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