A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure.

A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Research Abstract Details 

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A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Abstract Text:

Wei Wang,Andrei V Perepelov,Lu Feng,Sergei D Shevelev,Quan Wang,Sof'ya N Senchenkova,Weiqing Han,Yayue Li,Alexander S Shashkov,Yuriy A Knirel,Peter R Reeves,Lei Wang,

The O-antigen moiety of the LPS is one of the most variable cell surface components of the Gram-negative bacterial outer membrane. Variation is due to the presence of different sugars and sugar linkages. Here, it is reported that a group of Escherichia coli O serogroups (O17, O44, O73, O77 and O106), and the Salmonella enterica serogroup O : 6,14 (H), share a common four-sugar backbone O-subunit structure, and possess almost identical O-antigen gene clusters. Whereas the E. coli O77 antigen does not have any substitutions, the other O antigens in this group differ by the addition of one or two glucose side branches at various positions of the backbone. The O-antigen gene clusters for all members of the group encode only the proteins required for biosynthesis of the common four-sugar backbone. The identification of three genes within a putative prophage in the E. coli O44 genome is also reported; these genes are presumably involved in the glucosylation of the basic tetrasaccharide unit. This was confirmed by deletion of one of the genes, which encodes a putative glucosyltransferase. Structural analysis of the O antigen produced by the mutant strain demonstrated the absence of glucosylation. An O-antigen structure shared by five E. coli and one S. enterica serogroups, all of which have a long evolutionary history, suggests that the common backbone may be important for the survival of E. coli strains in the environment, or for their pathogenicity.

A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Publishing Authors By Initials

W Wang,AV Perepelov,L Feng,SD Shevelev,Q Wang,SN Senchenkova,W Han,Y Li,AS Shashkov,YA Knirel,PR Reeves,L Wang,

For similar bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica research abstracts see: bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica research

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A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 2159-67

Journal Abbreviation: Microbiology (Reading, Engl.)

ISSN: 1350-0872

DAY: 27

MONTH: Jul

YEAR: 2007

A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Information

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LANGUAGE: eng

NlmUniqueID: 9430468

A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Keywords Mesh Terms:

KEYWORDS: Salmonella enterica

MESH TERMS: genetics

Chemical & Substance for Abstract: A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Information

Substance Name: O Antigens

Registry Number: 0

Grant and Affiliation Information for A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure.

AFFILIATION: TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China.

Country: England

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MEDLINETA: Microbiology

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