A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats.

A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Research Abstract Details 

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A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Abstract Text:

Christina A Bursill,Paul D Roach,Christina A Bursill,Paul D Roach,

Green tea extracts have hypocholesterolaemic properties in epidemiological and animal intervention studies. Upregulation of the low-density lipoprotein (LDL) receptor may be one mechanism to explain this as it is the main way cholesterol is removed from the circulation. This study aimed to determine if a green tea extract could upregulate the hepatic LDL receptor in vivo in the rat. A green tea extract (GTE) enriched in its anti-oxidant constituents, the catechins, was fed to rats (n = 6) at concentrations of either 0, 0.5, 1.0 or 2.0% (w/w) mixed in with their normal chow along with 0.25% (w/w) cholesterol for 12 days. Administration of the GTE had no effect on plasma total or LDL cholesterol concentrations but high-density lipoprotein significantly increased (41%; p < 0.05). Interestingly, there was a significant increase in LDL receptor binding activity (2.7-fold) and LDL receptor protein (3.4-fold) in the 2% (w/w) treatment group compared to controls. There were also significant reductions in liver total and unesterified cholesterol (40%). Administration of the GTE significantly reduced cholesterol absorption (24%) but did not affect cholesterol synthesis. These results show that, despite no effect on plasma cholesterol, the GTE upregulated the LDL receptor in vivo. This appears to be via a reduction in liver cholesterol concentration and suggests that the green tea extract was able to increase the efflux of cholesterol from liver cells.

A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Publishing Authors By Initials

CA Bursill,PD Roach,CA Bursill,PD Roach,

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A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lipids

VOLUME: 42

Page Numbers: 621-7

Journal Abbreviation: Lipids

ISSN: 0024-4201

DAY: 21

MONTH: 06

YEAR: 2007

A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Information

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LANGUAGE: eng

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AFFILIATION: Heart Research Institute, University of Sydney, 114 Pyrmont Bridge Road, Camperdown, NSW 2050, Australia. bursillc@hri.org.au

Country: United States

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MEDLINETA: Lipids

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