A green GEM: intriguing analogies with animal geminin.

A green GEM: intriguing analogies with animal geminin. Research Abstract Details 

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A green GEM: intriguing analogies with animal geminin. Abstract Text:

Elena Caro,Crisanto Gutierrez,Elena Caro,Crisanto Gutierrez,

The transition of precursor cells from an undifferentiated proliferative state to differentiated cells with specific fates is of primary importance for multicellular organisms. Animals and plants have evolved two unrelated proteins, geminin and GEM, respectively, that play analogous roles in regulating this transition. These proteins are involved, probably in early G1 phase of the cell cycle, in regulating the expression of genes involved in cell fate and initiation of differentiation. They also interact with Cdt1, a component of the pre-replication complexes involved in DNA replication licensing in early G1 phase. The interaction of geminin and GEM with Cdt1 and transcriptional regulators is competitive, suggesting that these interactions can play a pivotal role in coordinating DNA replication, cell division and cell fate decisions.

A green GEM: intriguing analogies with animal geminin. Publishing Authors By Initials

E Caro,C Gutierrez,E Caro,C Gutierrez,

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A green GEM: intriguing analogies with animal geminin. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in cell biology

VOLUME: 17

Page Numbers: 580-5

Journal Abbreviation: Trends Cell Biol.

ISSN: 0962-8924

DAY: 9

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9200566

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Grant and Affiliation Information for A green GEM: intriguing analogies with animal geminin.

AFFILIATION: Centro de Biologia Molecular "Severo Ochoa", Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Country: England

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MEDLINETA: Trends Cell Biol

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